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10.1007/s10096-020-04139-5

http://scihub22266oqcxt.onion/10.1007/s10096-020-04139-5
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33512616!7843881!33512616
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suck abstract from ncbi


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pmid33512616      Eur+J+Clin+Microbiol+Infect+Dis 2021 ; 40 (6): 1343-1349
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  • Antibody response in patients admitted to the hospital with suspected SARS-CoV-2 infection: results from a multicenter study across Spain #MMPMID33512616
  • Fuentes A; Serrano-Conde E; Roldan C; Benito-Ruesca R; Mejias G; Sampedro A; March-Rosello G; Fernandez-Natal I; Esperalba J; Rodriguez MJ; Martinez de Aguirre P; Salas C; Roc ML; Soria LM; Parra-Grande M; Montero MD; Fernandez-Roblas R; Franco-Alvarez de Luna F; Lozano C; Garcia F
  • Eur J Clin Microbiol Infect Dis 2021[Jun]; 40 (6): 1343-1349 PMID33512616show ga
  • AIM: To evaluate the serological response against SARS-CoV-2 in a multicenter study representative of the Spanish COVID pandemic. METHODS: IgG and IgM + IgA responses were measured on 1466 samples from 1236 Spanish COVID-19 patients admitted to the hospital, two commercial ELISA kits (Vircell SL, Spain) based on the detection of antibodies against the viral spike protein and nucleoprotein, were used. RESULTS: Approximately half of the patients presented antibodies (56.8% were IgM + IgA positive and 43.0% were IgG positive) as soon as 2 days after the first positive PCR result. Serological test positivity increased with time from the PCR test, and 10 days after the first PCR result, 91.5% and 88.0% of the patients presented IgM + IgA and IgG antibodies, respectively. CONCLUSION: The high values of sensitivity attained in the present study from a relatively early period of time after hospitalization support the use of the evaluated serological assays as supplementary diagnostic tests for the clinical management of COVID-19.
  • |*Antibody Formation[MESH]
  • |Adolescent[MESH]
  • |Adult[MESH]
  • |Age Factors[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |Antibodies, Viral/*blood[MESH]
  • |COVID-19 Serological Testing[MESH]
  • |COVID-19/*immunology[MESH]
  • |Coronavirus Nucleocapsid Proteins/immunology[MESH]
  • |Enzyme-Linked Immunosorbent Assay[MESH]
  • |Female[MESH]
  • |Hospitalization[MESH]
  • |Humans[MESH]
  • |Immunoglobulin A[MESH]
  • |Immunoglobulin G[MESH]
  • |Immunoglobulin M[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Phosphoproteins/immunology[MESH]
  • |Sensitivity and Specificity[MESH]
  • |Sex Factors[MESH]
  • |Spain[MESH]
  • |Spike Glycoprotein, Coronavirus/immunology[MESH]


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