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Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Eur+J+Clin+Microbiol+Infect+Dis 2021 ; 40 (6): 1343-1349 Nephropedia Template TP
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Antibody response in patients admitted to the hospital with suspected SARS-CoV-2 infection: results from a multicenter study across Spain #MMPMID33512616
Fuentes A; Serrano-Conde E; Roldan C; Benito-Ruesca R; Mejias G; Sampedro A; March-Rosello G; Fernandez-Natal I; Esperalba J; Rodriguez MJ; Martinez de Aguirre P; Salas C; Roc ML; Soria LM; Parra-Grande M; Montero MD; Fernandez-Roblas R; Franco-Alvarez de Luna F; Lozano C; Garcia F
AIM: To evaluate the serological response against SARS-CoV-2 in a multicenter study representative of the Spanish COVID pandemic. METHODS: IgG and IgM + IgA responses were measured on 1466 samples from 1236 Spanish COVID-19 patients admitted to the hospital, two commercial ELISA kits (Vircell SL, Spain) based on the detection of antibodies against the viral spike protein and nucleoprotein, were used. RESULTS: Approximately half of the patients presented antibodies (56.8% were IgM + IgA positive and 43.0% were IgG positive) as soon as 2 days after the first positive PCR result. Serological test positivity increased with time from the PCR test, and 10 days after the first PCR result, 91.5% and 88.0% of the patients presented IgM + IgA and IgG antibodies, respectively. CONCLUSION: The high values of sensitivity attained in the present study from a relatively early period of time after hospitalization support the use of the evaluated serological assays as supplementary diagnostic tests for the clinical management of COVID-19.