Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1038/s41598-021-82221-4 http://scihub22266oqcxt.onion/10.1038/s41598-021-82221-4 33510359!7844278!33510359     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2021 ; 11 (1): 2459 Nephropedia Template TP {{tp|p=33510359|t=2021. Meta-analysis of host transcriptional responses to SARS-CoV-2 infection reveals their manifestation in human tumors |pdf=|usr=}}{{33510359}} gab.com Text Meta-analysis of host transcriptional responses to SARS-CoV-2 infection reveals their manifestation in human tumors JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=33510359 #FOAvip A deeper understanding of the molecular biology of SARS-CoV-2 infection, including the host response to the virus, is urgently needed. Commonalities exist between the host immune response to viral infections and cancer. Here, we defined transcriptional signatures of SARS-CoV-2 infection involving hundreds of genes common across lung adenocarcinoma cell lines (A549, Calu-3) and normal human bronchial epithelial cells (NHBE), with additional signatures being specific to one or both adenocarcinoma lines. Cross-examining eight transcriptomic databases, we found that host transcriptional responses of lung adenocarcinoma cells to SARS-CoV-2 infection shared broad similarities with host responses to multiple viruses across different model systems and patient samples. Furthermore, these SARS-CoV-2 transcriptional signatures were manifested within specific subsets of human cancer, involving ~ 20% of cases across a wide range of histopathological types. These cancer subsets show immune cell infiltration and inflammation and involve pathways linked to the SARS-CoV-2 response, such as immune checkpoint, IL-6, type II interferon signaling, and NF-kappaB. The cell line data represented immune responses activated specifically within the cancer cells of the tumor. Common genes and pathways implicated as part of the viral host response point to therapeutic strategies that may apply to both SARS-CoV-2 and cancer. Twit Text FOAVip Meta-analysis of host transcriptional responses to SARS-CoV-2 infection reveals their manifestation in human tumors ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=33510359 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33510359 #FOAvip English Wikipedia <ref>{{Cite pmid|33510359}}</ref> Meta-analysis of host transcriptional responses to SARS-CoV-2 infection reveals their manifestation in human tumors #MMPMID33510359 Chen F; Zhang Y; Sucgang R; Ramani S; Corry D; Kheradmand F; Creighton CJ Sci Rep 2021[Jan]; 11 (1): 2459 PMID33510359show ga A deeper understanding of the molecular biology of SARS-CoV-2 infection, including the host response to the virus, is urgently needed. Commonalities exist between the host immune response to viral infections and cancer. Here, we defined transcriptional signatures of SARS-CoV-2 infection involving hundreds of genes common across lung adenocarcinoma cell lines (A549, Calu-3) and normal human bronchial epithelial cells (NHBE), with additional signatures being specific to one or both adenocarcinoma lines. Cross-examining eight transcriptomic databases, we found that host transcriptional responses of lung adenocarcinoma cells to SARS-CoV-2 infection shared broad similarities with host responses to multiple viruses across different model systems and patient samples. Furthermore, these SARS-CoV-2 transcriptional signatures were manifested within specific subsets of human cancer, involving ~ 20% of cases across a wide range of histopathological types. These cancer subsets show immune cell infiltration and inflammation and involve pathways linked to the SARS-CoV-2 response, such as immune checkpoint, IL-6, type II interferon signaling, and NF-kappaB. The cell line data represented immune responses activated specifically within the cancer cells of the tumor. Common genes and pathways implicated as part of the viral host response point to therapeutic strategies that may apply to both SARS-CoV-2 and cancer. |A549 Cells[MESH] |Bronchi/metabolism[MESH] |COVID-19/*genetics/metabolism[MESH] |Epithelial Cells/metabolism/virology[MESH] |Host Microbial Interactions/*physiology[MESH] |Humans[MESH] |Immunity[MESH] |Lung Neoplasms/pathology/virology[MESH] |SARS-CoV-2/genetics/metabolism/*physiology[MESH] |Transcription, Genetic[MESH] |Transcriptome[MESH]Meta-analysis of host transcriptional responses to SARS-CoV-2 infectio(epmc).pdf DeepDyve Pubget Overpricing