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10.1038/s41598-021-81862-9 http://scihub22266oqcxt.onion/10.1038/s41598-021-81862-9 33510275!7843981!33510275     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2021 ; 11 (1): 2608 Nephropedia Template TP {{tp|p=33510275|t=2021. SARS-CoV-2 infection elicits a rapid neutralizing antibody response that correlates with disease severity |pdf=|usr=}}{{33510275}} gab.com Text SARS-CoV-2 infection elicits a rapid neutralizing antibody response that correlates with disease severity JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=33510275 #FOAvip The protective effect of neutralizing antibodies in SARS-CoV-2 infected individuals is not yet well defined. To address this issue, we have analyzed the kinetics of neutralizing antibody responses and their association with disease severity. Between March and May 2020, the prospective KING study enrolled 72 COVID-19+ participants grouped according to disease severity. SARS-CoV-2 infection was diagnosed by serological and virological tests. Plasma neutralizing responses were assessed against replicative virus and pseudoviral particles. Multiple regression and non-parametric tests were used to analyze dependence of parameters. The magnitude of neutralizing titers significantly increased with disease severity. Hospitalized individuals developed higher titers compared to mild-symptomatic and asymptomatic individuals, which together showed titers below the detection limit in 50% of cases. Longitudinal analysis confirmed the strong differences in neutralizing titers between non-hospitalized and hospitalized participants and showed rapid kinetics of appearance of neutralizing antibodies (50% and 80% of maximal activity reached after 11 and 17 days after symptoms onset, respectively) in hospitalized patients. No significant impact of age, gender or treatment on the neutralizing titers was observed in this limited cohort. These data identify a clear association of humoral immunity with disease severity and point to immune mechanisms other than antibodies as relevant players in COVID-19 protection. Twit Text FOAVip SARS-CoV-2 infection elicits a rapid neutralizing antibody response that correlates with disease severity ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=33510275 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33510275 #FOAvip English Wikipedia <ref>{{Cite pmid|33510275}}</ref> SARS-CoV-2 infection elicits a rapid neutralizing antibody response that correlates with disease severity #MMPMID33510275 Trinite B; Tarres-Freixas F; Rodon J; Pradenas E; Urrea V; Marfil S; Rodriguez de la Concepcion ML; Avila-Nieto C; Aguilar-Gurrieri C; Barajas A; Ortiz R; Paredes R; Mateu L; Valencia A; Guallar V; Ruiz L; Grau E; Massanella M; Puig J; Chamorro A; Izquierdo-Useros N; Segales J; Clotet B; Carrillo J; Vergara-Alert J; Blanco J Sci Rep 2021[Jan]; 11 (1): 2608 PMID33510275show ga The protective effect of neutralizing antibodies in SARS-CoV-2 infected individuals is not yet well defined. To address this issue, we have analyzed the kinetics of neutralizing antibody responses and their association with disease severity. Between March and May 2020, the prospective KING study enrolled 72 COVID-19+ participants grouped according to disease severity. SARS-CoV-2 infection was diagnosed by serological and virological tests. Plasma neutralizing responses were assessed against replicative virus and pseudoviral particles. Multiple regression and non-parametric tests were used to analyze dependence of parameters. The magnitude of neutralizing titers significantly increased with disease severity. Hospitalized individuals developed higher titers compared to mild-symptomatic and asymptomatic individuals, which together showed titers below the detection limit in 50% of cases. Longitudinal analysis confirmed the strong differences in neutralizing titers between non-hospitalized and hospitalized participants and showed rapid kinetics of appearance of neutralizing antibodies (50% and 80% of maximal activity reached after 11 and 17 days after symptoms onset, respectively) in hospitalized patients. No significant impact of age, gender or treatment on the neutralizing titers was observed in this limited cohort. These data identify a clear association of humoral immunity with disease severity and point to immune mechanisms other than antibodies as relevant players in COVID-19 protection. |Adaptive Immunity/immunology[MESH] |Adult[MESH] |Antibodies, Neutralizing/blood/*immunology[MESH] |Antibodies, Viral/*immunology[MESH] |COVID-19/blood/*immunology[MESH] |Cohort Studies[MESH] |Female[MESH] |Humans[MESH] |Immunity, Humoral/immunology[MESH] |Immunoglobulin G/blood[MESH] |Male[MESH] |Middle Aged[MESH] |Prospective Studies[MESH] |SARS-CoV-2/*immunology[MESH] |Severity of Illness Index[MESH]SARS-CoV-2 infection elicits a rapid neutralizing antibody response th(epmc).pdf DeepDyve Pubget Overpricing