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10.1016/j.orcp.2021.01.004

http://scihub22266oqcxt.onion/10.1016/j.orcp.2021.01.004
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suck abstract from ncbi


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pmid33509701      Obes+Res+Clin+Pract 2021 ; 15 (2): 163-171
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  • COVID-19 severity in obese patients: Potential mechanisms and molecular targets for clinical intervention #MMPMID33509701
  • Sharma JR; Yadav UCS
  • Obes Res Clin Pract 2021[Mar]; 15 (2): 163-171 PMID33509701show ga
  • With the global spread of SARS-CoV-2, millions of people have been affected leading to the declaration of coronavirus disease 2019 (COVID-19) as a pandemic by the WHO. Several studies have linked the severity of COVID-19 cases and increased fatality in patients with obesity and other comorbid conditions such as diabetes, cardiovascular diseases, hypertension, and kidney disease. Obesity, a metabolically deranged condition, establishes a low-grade chronic inflammation in the body, which affects different organs and promotes the development of several other diseases. The ways in which SARS-CoV-2 infection aggravates the already overloaded body organs with inflammation or vice versa has perplexed the researchers. As a result, there is an intensified search for the clear-cut mechanism to understand the link of obesity with the increased severity of COVID-19 in obese patients. In this article we have discussed various mechanisms linking obesity, inflammation, and COVID-19 to enhance the understanding of the disease process and help the clinicians and scientists develop potential cellular, molecular and metabolic targets for clinical intervention and management of COVID-19 severity in obese patients.
  • |*Body Mass Index[MESH]
  • |COVID-19 Drug Treatment[MESH]
  • |COVID-19/epidemiology/metabolism/*pathology[MESH]
  • |Comorbidity[MESH]
  • |Humans[MESH]
  • |Inflammation/drug therapy/*metabolism[MESH]
  • |Obesity/epidemiology/metabolism/*pathology[MESH]
  • |Pandemics[MESH]
  • |SARS-CoV-2[MESH]


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