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10.1016/j.cyto.2021.155430 http://scihub22266oqcxt.onion/10.1016/j.cyto.2021.155430 33508651!7810030!33508651     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cytokine 2021 ; 140 (ä): 155430 Nephropedia Template TP {{tp|p=33508651|t=2021. ACE2 expression is related to the interferon response in airway epithelial cells but is that functional for SARS-CoV-2 entry?|pdf=|usr=}}{{33508651}} gab.com Text ACE2 expression is related to the interferon response in airway epithelial cells but is that functional for SARS-CoV-2 entry JO: Cytokine http://www.kidney.de/pget.php?&tw=1&pmid=33508651 #FOAvip In vitro interferon (IFN)alpha treatment of primary human upper airway basal cells has been shown to drive ACE2 expression, the receptor of SARS-CoV-2. The protease furin is also involved in mediating SARS-CoV-2 and other viral infections, although its association with early IFN response has not been evaluated yet. In order to assess the in vivo relationship between ACE2 and furin expression and the IFN response in nasopharyngeal cells, we first examined ACE2 and furin levels and their correlation with the well-known marker of IFNs' activation, ISG15, in children (n = 59) and adults (n = 48), during respiratory diseases not caused by SARS-CoV-2. A strong positive correlation was found between ACE2 expression, but not of furin, and ISG15 in all patients analyzed. In addition, type I and III IFN stimulation experiments were performed to examine the IFN-mediated activation of ACE2 isoforms (full-length and truncated) and furin in epithelial cell lines. Following all the IFNs treatments, only the truncated ACE2 levels, were upregulated significantly in the A549 and Calu3 cells, in particular by type I IFNs. If confirmed in vivo following IFNs' activation, the induction of the truncated ACE2 isoform only would not enhance the risk of SARS-CoV-2 infection in the respiratory tract. Twit Text FOAVip ACE2 expression is related to the interferon response in airway epithelial cells but is that functional for SARS-CoV-2 entry ????Cytokine http://www.kidney.de/pget.php?&tw=1&pmid=33508651 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33508651 #FOAvip English Wikipedia <ref>{{Cite pmid|33508651}}</ref> ACE2 expression is related to the interferon response in airway epithelial cells but is that functional for SARS-CoV-2 entry? #MMPMID33508651 Scagnolari C; Bitossi C; Viscido A; Frasca F; Oliveto G; Scordio M; Petrarca L; Mancino E; Nenna R; Riva E; De Vito C; Midulla F; Antonelli G; Pierangeli A Cytokine 2021[Apr]; 140 (ä): 155430 PMID33508651show ga In vitro interferon (IFN)alpha treatment of primary human upper airway basal cells has been shown to drive ACE2 expression, the receptor of SARS-CoV-2. The protease furin is also involved in mediating SARS-CoV-2 and other viral infections, although its association with early IFN response has not been evaluated yet. In order to assess the in vivo relationship between ACE2 and furin expression and the IFN response in nasopharyngeal cells, we first examined ACE2 and furin levels and their correlation with the well-known marker of IFNs' activation, ISG15, in children (n = 59) and adults (n = 48), during respiratory diseases not caused by SARS-CoV-2. A strong positive correlation was found between ACE2 expression, but not of furin, and ISG15 in all patients analyzed. In addition, type I and III IFN stimulation experiments were performed to examine the IFN-mediated activation of ACE2 isoforms (full-length and truncated) and furin in epithelial cell lines. Following all the IFNs treatments, only the truncated ACE2 levels, were upregulated significantly in the A549 and Calu3 cells, in particular by type I IFNs. If confirmed in vivo following IFNs' activation, the induction of the truncated ACE2 isoform only would not enhance the risk of SARS-CoV-2 infection in the respiratory tract. |A549 Cells[MESH] |Adult[MESH] |Angiotensin-Converting Enzyme 2/*genetics[MESH] |Antiviral Agents/metabolism/pharmacology[MESH] |COVID-19/*prevention & control/virology[MESH] |Cell Line, Tumor[MESH] |Child[MESH] |Cytokines/genetics[MESH] |Epithelial Cells/*drug effects/metabolism[MESH] |Gene Expression/*drug effects[MESH] |Humans[MESH] |Interferons/metabolism/*pharmacology[MESH] |Lung/cytology[MESH] |Middle Aged[MESH] |SARS-CoV-2/*drug effects/physiology[MESH]ACE2 expression is related to the interferon response in airway epithe(epmc).pdf DeepDyve Pubget Overpricing