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10.26355/eurrev_202101_24428

http://scihub22266oqcxt.onion/10.26355/eurrev_202101_24428
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33506949!ä!33506949

suck abstract from ncbi


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pmid33506949      Eur+Rev+Med+Pharmacol+Sci 2021 ; 25 (1): 556-566
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  • Quinacrine as a potential treatment for COVID-19 virus infection #MMPMID33506949
  • Pineda B; Perez de la Cruz V; Hernandez Pando R; Sotelo J
  • Eur Rev Med Pharmacol Sci 2021[Jan]; 25 (1): 556-566 PMID33506949show ga
  • A novel coronavirus named severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a current outbreak of infection termed Coronavirus Disease 2019 (COVID-19) by the World Health Organization (WHO). COVID-19 is currently a global pandemic that may cause close to half a billion deaths around the world. Until now, there is no effective treatment for COVID-19. Quinacrine (Qx) has been used since the 1930s as preventive antimalarial compound. It is a recognized small molecule inhibitor of RNA virus replication, with known anti-prion activity, and identified as a potent Ebola virus inhibitor both in vitro and in vivo. Recently, Qx has showed anti-SARS-CoV-2 activity. Herein, we review the potential mechanisms associated with quinacrine as an antiviral compound.
  • |*COVID-19 Drug Treatment[MESH]
  • |*SARS-CoV-2/drug effects[MESH]
  • |Animals[MESH]
  • |Antiviral Agents/administration & dosage/adverse effects/*pharmacology[MESH]
  • |COVID-19/immunology[MESH]
  • |Cell Line[MESH]
  • |Cytokine Release Syndrome/immunology/prevention & control[MESH]
  • |Cytokines/immunology[MESH]
  • |Humans[MESH]
  • |Mice[MESH]
  • |Quinacrine/administration & dosage/adverse effects/*pharmacology[MESH]


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