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10.1038/s41598-021-81638-1 http://scihub22266oqcxt.onion/10.1038/s41598-021-81638-1 33504824!7841145!33504824     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33504824&cmd=llinks): Failed to open stream: HTTP request failed! 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Altered high-density lipoprotein composition and functions during severe COVID-19 |pdf=|usr=}}{{33504824}} gab.com Text Altered high-density lipoprotein composition and functions during severe COVID-19 JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=33504824 #FOAvip Coronavirus disease 2019 (COVID-19) pandemic is affecting millions of patients worldwide. The consequences of initial exposure to SARS-CoV-2 go beyond pulmonary damage, with a particular impact on lipid metabolism. Decreased levels in HDL-C were reported in COVID-19 patients. Since HDL particles display antioxidant, anti-inflammatory and potential anti-infectious properties, we aimed at characterizing HDL proteome and functionality during COVID-19 relative to healthy subjects. HDLs were isolated from plasma of 8 severe COVID-19 patients sampled at admission to intensive care unit (Day 1, D1) at D3 and D7, and from 16 sex- and age-matched healthy subjects. Proteomic analysis was performed by LC-MS/MS. The relative amounts of proteins identified in HDLs were compared between COVID-19 and controls. apolipoprotein A-I and paraoxonase 1 were confirmed by Western-blot analysis to be less abundant in COVID-19 versus controls, whereas serum amyloid A and alpha-1 antitrypsin were higher. HDLs from patients were less protective in endothelial cells stiumalted by TNFalpha (permeability, VE-cadherin disorganization and apoptosis). In these conditions, HDL inhibition of apoptosis was blunted in COVID-19 relative to controls. In conclusion, we show major changes in HDL proteome and decreased functionality in severe COVID-19 patients. Twit Text FOAVip Altered high-density lipoprotein composition and functions during severe COVID-19 ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=33504824 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33504824 #FOAvip English Wikipedia <ref>{{Cite pmid|33504824}}</ref> Altered high-density lipoprotein composition and functions during severe COVID-19 #MMPMID33504824 Begue F; Tanaka S; Mouktadi Z; Rondeau P; Veeren B; Diotel N; Tran-Dinh A; Robert T; Velia E; Mavingui P; Lagrange-Xelot M; Montravers P; Couret D; Meilhac O Sci Rep 2021[Jan]; 11 (1): 2291 PMID33504824show ga Coronavirus disease 2019 (COVID-19) pandemic is affecting millions of patients worldwide. The consequences of initial exposure to SARS-CoV-2 go beyond pulmonary damage, with a particular impact on lipid metabolism. Decreased levels in HDL-C were reported in COVID-19 patients. Since HDL particles display antioxidant, anti-inflammatory and potential anti-infectious properties, we aimed at characterizing HDL proteome and functionality during COVID-19 relative to healthy subjects. HDLs were isolated from plasma of 8 severe COVID-19 patients sampled at admission to intensive care unit (Day 1, D1) at D3 and D7, and from 16 sex- and age-matched healthy subjects. Proteomic analysis was performed by LC-MS/MS. The relative amounts of proteins identified in HDLs were compared between COVID-19 and controls. apolipoprotein A-I and paraoxonase 1 were confirmed by Western-blot analysis to be less abundant in COVID-19 versus controls, whereas serum amyloid A and alpha-1 antitrypsin were higher. HDLs from patients were less protective in endothelial cells stiumalted by TNFalpha (permeability, VE-cadherin disorganization and apoptosis). In these conditions, HDL inhibition of apoptosis was blunted in COVID-19 relative to controls. In conclusion, we show major changes in HDL proteome and decreased functionality in severe COVID-19 patients. |Apolipoprotein A-I/blood[MESH] |Aryldialkylphosphatase/analysis/blood[MESH] |COVID-19/*blood/epidemiology/pathology/virology[MESH] |Case-Control Studies[MESH] |Chromatography, Liquid/methods[MESH] |Endothelial Cells/pathology[MESH] |Female[MESH] |France/epidemiology[MESH] |Humans[MESH] |Lipoproteins, HDL/*blood[MESH] |Male[MESH] |Middle Aged[MESH] |Pandemics[MESH] |Proteome/metabolism[MESH] |Proteomics/methods[MESH] |SARS-CoV-2/isolation & purification[MESH] |Serum Amyloid A Protein/metabolism[MESH] |Tandem Mass Spectrometry/methods[MESH] |Tumor Necrosis Factor-alpha/blood[MESH]Altered high-density lipoprotein composition and functions during seve(epmc).pdf DeepDyve Pubget Overpricing