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10.3390/molecules26030618

http://scihub22266oqcxt.onion/10.3390/molecules26030618
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33504092!7865783!33504092
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suck abstract from ncbi


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pmid33504092      Molecules 2021 ; 26 (3): ä
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  • From Angiotensin II to Cyclic Peptides and Angiotensin Receptor Blockers (ARBs): Perspectives of ARBs in COVID-19 Therapy #MMPMID33504092
  • Matsoukas J; Apostolopoulos V; Zulli A; Moore G; Kelaidonis K; Moschovou K; Mavromoustakos T
  • Molecules 2021[Jan]; 26 (3): ä PMID33504092show ga
  • The octapeptide hormone angiotensin II is one of the most studied peptides with the aim of designing and synthesizing non-peptide mimetics for oral administration. To achieve this, cyclizations at different positions within the peptide molecule has been a useful strategy to define the active conformation. These studies on angiotensin II led to the discovery of Sarmesin, a type II angiotensin II antagonist, and the breakthrough non-peptide mimetic Losartan, the first in a series of sartans marketed as a new generation of anti-hypertensive drugs in the 1990s. Angiotensin II receptor blockers (ARBS) and angiotensin I converting enzyme inhibitors (ACEI) were recently reported to protect hypertensive patients infected with SARS-CoV-2. The renin-angiotensin system (RAS) inhibitors reduce excess angiotensin II and increase antagonist heptapeptides alamandine and aspamandine which counterbalance angiotensin II and maintain homeostasis and vasodilation.
  • |*COVID-19 Drug Treatment[MESH]
  • |Angiotensin II/*therapeutic use[MESH]
  • |Angiotensin Receptor Antagonists/*therapeutic use[MESH]
  • |COVID-19/virology[MESH]
  • |Humans[MESH]
  • |Hypertension/drug therapy[MESH]
  • |Renin-Angiotensin System/drug effects[MESH]


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