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Deprecated: Implicit conversion from float 298.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Microorganisms 2021 ; 9 (2): ä Nephropedia Template TP
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Diagnostic Efficiency of Three Fully Automated Serology Assays and Their Correlation with a Novel Surrogate Virus Neutralization Test in Symptomatic and Asymptomatic SARS-COV-2 Individuals #MMPMID33504067
Microorganisms 2021[Jan]; 9 (2): ä PMID33504067show ga
To support the deployment of serology assays for population screening during the COVID-19 pandemic, we compared the performance of three fully automated SARS-CoV-2 IgG assays: Mindray CL-900i((R)) (target: spike [S] and nucleocapsid [N]), BioMerieux VIDAS((R))3 (target: receptor-binding domain [RBD]) and Diasorin LIAISON((R))XL (target: S1 and S2 subunits). A total of 111 SARS-CoV-2 RT-PCR- positive samples collected at >/= 21 days post symptom onset, and 127 pre-pandemic control samples were included. Diagnostic performance was assessed in correlation to RT-PCR and a surrogate virus-neutralizing test (sVNT). Moreover, cross-reactivity with other viral antibodies was investigated. Compared to RT-PCR, LIAISON((R))XL showed the highest overall specificity (100%), followed by VIDAS((R))3 (98.4%) and CL-900i((R)) (95.3%). The highest sensitivity was demonstrated by CL-900i((R)) (90.1%), followed by VIDAS((R))3 (88.3%) and LIAISON((R))XL (85.6%). The sensitivity of all assays was higher in symptomatic patients (91.1-98.2%) compared to asymptomatic patients (78.4-80.4%). In correlation to sVNT, all assays showed excellent sensitivities (92.2-96.1%). In addition, VIDAS((R))3 demonstrated the best correlation (r = 0.75) with the sVNT. The present study provides insights on the performance of three fully automated assays, which could help diagnostic laboratories in the choice of a particular assay according to the intended use.