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10.1016/j.celrep.2020.108666 http://scihub22266oqcxt.onion/10.1016/j.celrep.2020.108666 33503420!7837128!33503420     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Rep 2021 ; 34 (4): 108666 Nephropedia Template TP {{tp|p=33503420|t=2021. The immunodominant and neutralization linear epitopes for SARS-CoV-2 |pdf=|usr=}}{{33503420}} gab.com Text The immunodominant and neutralization linear epitopes for SARS-CoV-2 JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=33503420 #FOAvip Although vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are under development, the antigen epitopes on the virus and their immunogenicity are poorly understood. Here, we simulate the 3D structures and predict the B cell epitopes on the spike (S), envelope (E), membrane (M), and nucleocapsid (N) proteins of SARS-CoV-2 using structure-based approaches and validate epitope immunogenicity by immunizing mice. Almost all 33 predicted epitopes effectively induce antibody production, six of these are immunodominant epitopes in individuals, and 23 are conserved within SARS-CoV-2, SARS-CoV, and bat coronavirus RaTG13. We find that the immunodominant epitopes of individuals with domestic (China) SARS-CoV-2 are different from those of individuals with imported (Europe) SARS-CoV-2, which may be caused by mutations on the S (G614D) and N proteins. Importantly, we find several epitopes on the S protein that elicit neutralizing antibodies against D614 and G614 SARS-CoV-2, which can contribute to vaccine design against coronaviruses. Twit Text FOAVip The immunodominant and neutralization linear epitopes for SARS-CoV-2 ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=33503420 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33503420 #FOAvip English Wikipedia <ref>{{Cite pmid|33503420}}</ref> The immunodominant and neutralization linear epitopes for SARS-CoV-2 #MMPMID33503420 Lu S; Xie XX; Zhao L; Wang B; Zhu J; Yang TR; Yang GW; Ji M; Lv CP; Xue J; Dai EH; Fu XM; Liu DQ; Zhang L; Hou SJ; Yu XL; Wang YL; Gao HX; Shi XH; Ke CW; Ke BX; Jiang CG; Liu RT Cell Rep 2021[Jan]; 34 (4): 108666 PMID33503420show ga Although vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are under development, the antigen epitopes on the virus and their immunogenicity are poorly understood. Here, we simulate the 3D structures and predict the B cell epitopes on the spike (S), envelope (E), membrane (M), and nucleocapsid (N) proteins of SARS-CoV-2 using structure-based approaches and validate epitope immunogenicity by immunizing mice. Almost all 33 predicted epitopes effectively induce antibody production, six of these are immunodominant epitopes in individuals, and 23 are conserved within SARS-CoV-2, SARS-CoV, and bat coronavirus RaTG13. We find that the immunodominant epitopes of individuals with domestic (China) SARS-CoV-2 are different from those of individuals with imported (Europe) SARS-CoV-2, which may be caused by mutations on the S (G614D) and N proteins. Importantly, we find several epitopes on the S protein that elicit neutralizing antibodies against D614 and G614 SARS-CoV-2, which can contribute to vaccine design against coronaviruses. |Adolescent[MESH] |Adult[MESH] |Aged[MESH] |Animals[MESH] |Antibodies, Neutralizing/immunology[MESH] |Antibodies, Viral/immunology[MESH] |Antigens, Viral/immunology[MESH] |COVID-19 Vaccines/immunology[MESH] |COVID-19/immunology/therapy[MESH] |Child[MESH] |Coronavirus Nucleocapsid Proteins/*immunology[MESH] |Epitopes, B-Lymphocyte/*immunology/metabolism[MESH] |Female[MESH] |Humans[MESH] |Male[MESH] |Mice[MESH] |Mice, Inbred BALB C[MESH] |Middle Aged[MESH] |SARS-CoV-2/*immunology[MESH] |Spike Glycoprotein, Coronavirus/*immunology[MESH] |Viral Matrix Proteins/*immunology[MESH] |Viroporin Proteins/*immunology[MESH]The immunodominant and neutralization linear epitopes for SARS-CoV-2 (epmc).pdf DeepDyve Pubget Overpricing