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10.1093/infdis/jiab053 http://scihub22266oqcxt.onion/10.1093/infdis/jiab053 33503244!7928807!33503244     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Infect+Dis 2021 ; 223 (9): 1503-1505 Nephropedia Template TP {{tp|p=33503244|t=2021. Neutrophils Set Extracellular Traps to Injure Lungs in Coronavirus Disease 2019 |pdf=|usr=}}{{33503244}} gab.com Text Neutrophils Set Extracellular Traps to Injure Lungs in Coronavirus Disease 2019 JO: J Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=33503244 #FOAvip SARS-CoV-2 induced lower respiratory tract (LRT) disease can deteriorate to acute respiratory distress syndrome (ARDS). Because the release of neutrophil extracellular traps (NETs) is implicated in ARDS pathogenesis, we investigated the presence of NETs and correlates of pathogenesis in blood and LRT samples of critically ill COVID-19 patients. Plasma NET levels peaked early after ICU admission and correlated with SARS-CoV-2 RNA load in sputum and levels of neutrophil-recruiting chemokines and inflammatory markers in plasma. Baseline plasma NET quantity correlated with disease severity, but was not associated with soluble markers of thrombosis nor with development of thrombosis. High NET levels were present in LRT samples and persisted during the course of COVID-19, consistent with the detection of NETs in bronchi and alveolar spaces in lung tissue from fatal COVID-19 patients. Thus, NETs are produced and retained in the LRT of critical COVID-19 patients and could contribute to SARS-CoV-2-induced ARDS pathology. Twit Text FOAVip Neutrophils Set Extracellular Traps to Injure Lungs in Coronavirus Disease 2019 ????J Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=33503244 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33503244 #FOAvip English Wikipedia <ref>{{Cite pmid|33503244}}</ref> Neutrophils Set Extracellular Traps to Injure Lungs in Coronavirus Disease 2019 #MMPMID33503244 Teluguakula N J Infect Dis 2021[May]; 223 (9): 1503-1505 PMID33503244show ga SARS-CoV-2 induced lower respiratory tract (LRT) disease can deteriorate to acute respiratory distress syndrome (ARDS). Because the release of neutrophil extracellular traps (NETs) is implicated in ARDS pathogenesis, we investigated the presence of NETs and correlates of pathogenesis in blood and LRT samples of critically ill COVID-19 patients. Plasma NET levels peaked early after ICU admission and correlated with SARS-CoV-2 RNA load in sputum and levels of neutrophil-recruiting chemokines and inflammatory markers in plasma. Baseline plasma NET quantity correlated with disease severity, but was not associated with soluble markers of thrombosis nor with development of thrombosis. High NET levels were present in LRT samples and persisted during the course of COVID-19, consistent with the detection of NETs in bronchi and alveolar spaces in lung tissue from fatal COVID-19 patients. Thus, NETs are produced and retained in the LRT of critical COVID-19 patients and could contribute to SARS-CoV-2-induced ARDS pathology. |*COVID-19[MESH] |*Extracellular Traps[MESH] |Critical Illness[MESH] |Humans[MESH] |Lung[MESH] |Neutrophils[MESH]Neutrophils Set Extracellular Traps to Injure Lungs in Coronavirus Dis(epmc).pdf DeepDyve Pubget Overpricing