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10.4149/BLL_2021_015 http://scihub22266oqcxt.onion/10.4149/BLL_2021_015 33502877!ä!33502877 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Bratisl+Lek+Listy 2021 ; 122 (2): 101-110 Nephropedia Template TP {{tp|p=33502877|t=2021. Are clarithromycin, azithromycin and their analogues effective in the treatment of COVID19?|pdf=|usr=}}{{33502877}} gab.com Text Are clarithromycin, azithromycin and their analogues effective in the treatment of COVID19 JO: Bratisl Lek Listy http://www.kidney.de/pget.php?&tw=1&pmid=33502877 #FOAvip BACKGROUND: SARS-CoV-2, which started in Wuhan and later affected the whole world, is the most important disease of the world today. Many ways to inhibit SARS-CoV-2 virus are sought to prevent the spread of this virus. Azithromycin and clarithromycin are considered for the treatment of the SARS-CoV-2 virus, which has a high similarity to previous colonic diseases. AIM: We aimed to determine whether azithromycin and clarithromycin, the RNA-dependent RNA polymerase protein inhibitor used in the treatment of COVID-19, is effective against SARS Cov-2 in silico. RESULTS AND CONCLUSION: The 503 analogues of azithromycin and clarithromycin were studied to target SARS-CoV-2 the RNA-dependent RNA polymerase protein inhibition. Maestro program was used to compare the inhibition activities of these analogues. A detailed comparison was made using the numerical value of many parameters obtained. ADME / T properties were then examined to determine the effects and reactions of analogues on human metabolism. In this study, the SARS-CoV2 virus is 6NUR and 6NUS, which is the RNA-dependent RNA polymerase protein. Among these proteins, the best inhibitor among the 503 analogues according to the docking score parameter was 9851445 with a great difference. This analogue was an analogue of azithromycin (Tab. 3, Fig. 6, Ref. 58). Twit Text FOAVip Are clarithromycin, azithromycin and their analogues effective in the treatment of COVID19 ????Bratisl Lek Listy http://www.kidney.de/pget.php?&tw=1&pmid=33502877 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33502877 #FOAvip English Wikipedia <ref>{{Cite pmid|33502877}}</ref> Are clarithromycin, azithromycin and their analogues effective in the treatment of COVID19? #MMPMID33502877 Gedikli MA; Tuzun B; Aktas A; Sayin K; Ataseven H Bratisl Lek Listy 2021[]; 122 (2): 101-110 PMID33502877show ga BACKGROUND: SARS-CoV-2, which started in Wuhan and later affected the whole world, is the most important disease of the world today. Many ways to inhibit SARS-CoV-2 virus are sought to prevent the spread of this virus. Azithromycin and clarithromycin are considered for the treatment of the SARS-CoV-2 virus, which has a high similarity to previous colonic diseases. AIM: We aimed to determine whether azithromycin and clarithromycin, the RNA-dependent RNA polymerase protein inhibitor used in the treatment of COVID-19, is effective against SARS Cov-2 in silico. RESULTS AND CONCLUSION: The 503 analogues of azithromycin and clarithromycin were studied to target SARS-CoV-2 the RNA-dependent RNA polymerase protein inhibition. Maestro program was used to compare the inhibition activities of these analogues. A detailed comparison was made using the numerical value of many parameters obtained. ADME / T properties were then examined to determine the effects and reactions of analogues on human metabolism. In this study, the SARS-CoV2 virus is 6NUR and 6NUS, which is the RNA-dependent RNA polymerase protein. Among these proteins, the best inhibitor among the 503 analogues according to the docking score parameter was 9851445 with a great difference. This analogue was an analogue of azithromycin (Tab. 3, Fig. 6, Ref. 58). |*COVID-19 Drug Treatment[MESH] |Antiviral Agents/pharmacology[MESH] |Azithromycin/pharmacology/*therapeutic use[MESH] |Clarithromycin/pharmacology/*therapeutic use[MESH] |Humans[MESH] |RNA, Viral[MESH]Are clarithromycin, azithromycin and their analogues effective in the (epmc).pdf DeepDyve Pubget Overpricing