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10.1002/cpt.2176

http://scihub22266oqcxt.onion/10.1002/cpt.2176
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33501997!8014571!33501997
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suck abstract from ncbi


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pmid33501997      Clin+Pharmacol+Ther 2021 ; 109 (4): 1116-1124
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  • Physiologically-Based Pharmacokinetic Modeling of Remdesivir and Its Metabolites to Support Dose Selection for the Treatment of Pediatric Patients With COVID-19 #MMPMID33501997
  • Lutz JD; Mathias A; German P; Pikora C; Reddy S; Kirby BJ
  • Clin Pharmacol Ther 2021[Apr]; 109 (4): 1116-1124 PMID33501997show ga
  • Severe coronavirus disease 2019 (COVID-19) disease, including multisystem inflammatory syndrome, has been reported in children. This report summarizes development of a remdesivir physiologically-based pharmacokinetic (PBPK) model that accurately describes observed adult remdesivir and metabolites exposure and predicts pediatric remdesivir and metabolites exposure. The adult PBPK model was applied to predict pediatric remdesivir and metabolites steady-state exposures using the Pediatric Population Model in SimCYP and incorporated the relevant physiologic and mechanistic information. Model development was based on adult phase I exposure data in healthy volunteers who were administered a 200-mg loading dose of remdesivir intravenous (IV) over 0.5 hours on Day 1, then 100-mg daily maintenance doses of IV over 0.5 hours starting on Day 2 and continuing through Days 5 or 10. Simulations indicated that use of the adult therapeutic remdesivir dosage regimen (200-mg loading dose on Day 1 then 100-mg daily maintenance dose starting on Day 2) in pediatric patients >/= 40 kg and a weight-based remdesivir dosage regimen (5-mg/kg loading dose on Day 1 then 2.5-mg/kg daily maintenance dose starting on Day 2) in pediatric patients weighing 2.5 to < 40 kg is predicted to maintain therapeutic exposures of remdesivir and its metabolites. The comprehensive PBPK model described in this report supported remdesivir dosing in planned pediatric clinical studies and dosing in the emergency use authorization and pediatric compassionate use programs that were initiated to support remdesivir as a treatment option during the pandemic.
  • |*COVID-19 Drug Treatment[MESH]
  • |Adenosine Monophosphate/administration & dosage/*analogs & derivatives/pharmacokinetics/therapeutic use[MESH]
  • |Adolescent[MESH]
  • |Alanine/administration & dosage/*analogs & derivatives/pharmacokinetics/therapeutic use[MESH]
  • |Antiviral Agents/*administration & dosage/*pharmacokinetics/therapeutic use[MESH]
  • |Area Under Curve[MESH]
  • |Body Weight[MESH]
  • |Child[MESH]
  • |Child, Preschool[MESH]
  • |Computer Simulation[MESH]
  • |Drug Dosage Calculations[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Infant[MESH]
  • |Male[MESH]
  • |Models, Biological[MESH]
  • |Pandemics[MESH]


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