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10.1093/ve/veaa098 http://scihub22266oqcxt.onion/10.1093/ve/veaa098 33500788!7798566!33500788     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Virus+Evol 2021 ; 7 (1): veaa098 Nephropedia Template TP {{tp|p=33500788|t=2021. Synonymous mutations and the molecular evolution of SARS-CoV-2 origins |pdf=|usr=}}{{33500788}} gab.com Text Synonymous mutations and the molecular evolution of SARS-CoV-2 origins JO: Virus Evol http://www.kidney.de/pget.php?&tw=1&pmid=33500788 #FOAvip Human severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is most closely related, by average genetic distance, to two coronaviruses isolated from bats, RaTG13 and RmYN02. However, there is a segment of high amino acid similarity between human SARS-CoV-2 and a pangolin-isolated strain, GD410721, in the receptor-binding domain (RBD) of the spike protein, a pattern that can be caused by either recombination or by convergent amino acid evolution driven by natural selection. We perform a detailed analysis of the synonymous divergence, which is less likely to be affected by selection than amino acid divergence, between human SARS-CoV-2 and related strains. We show that the synonymous divergence between the bat-derived viruses and SARS-CoV-2 is larger than between GD410721 and SARS-CoV-2 in the RBD, providing strong additional support for the recombination hypothesis. However, the synonymous divergence between pangolin strain and SARS-CoV-2 is also relatively high, which is not consistent with a recent recombination between them, instead, it suggests a recombination into RaTG13. We also find a 14-fold increase in the d(N) /d(S) ratio from the lineage leading to SARS-CoV-2 to the strains of the current pandemic, suggesting that the vast majority of nonsynonymous mutations currently segregating within the human strains have a negative impact on viral fitness. Finally, we estimate that the time to the most recent common ancestor of SARS-CoV-2 and RaTG13 or RmYN02 based on synonymous divergence is 51.71 years (95% CI, 28.11-75.31) and 37.02 years (95% CI, 18.19-55.85), respectively. Twit Text FOAVip Synonymous mutations and the molecular evolution of SARS-CoV-2 origins ????Virus Evol http://www.kidney.de/pget.php?&tw=1&pmid=33500788 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33500788 #FOAvip English Wikipedia <ref>{{Cite pmid|33500788}}</ref> Synonymous mutations and the molecular evolution of SARS-CoV-2 origins #MMPMID33500788 Wang H; Pipes L; Nielsen R Virus Evol 2021[Jan]; 7 (1): veaa098 PMID33500788show ga Human severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is most closely related, by average genetic distance, to two coronaviruses isolated from bats, RaTG13 and RmYN02. However, there is a segment of high amino acid similarity between human SARS-CoV-2 and a pangolin-isolated strain, GD410721, in the receptor-binding domain (RBD) of the spike protein, a pattern that can be caused by either recombination or by convergent amino acid evolution driven by natural selection. We perform a detailed analysis of the synonymous divergence, which is less likely to be affected by selection than amino acid divergence, between human SARS-CoV-2 and related strains. We show that the synonymous divergence between the bat-derived viruses and SARS-CoV-2 is larger than between GD410721 and SARS-CoV-2 in the RBD, providing strong additional support for the recombination hypothesis. However, the synonymous divergence between pangolin strain and SARS-CoV-2 is also relatively high, which is not consistent with a recent recombination between them, instead, it suggests a recombination into RaTG13. We also find a 14-fold increase in the d(N) /d(S) ratio from the lineage leading to SARS-CoV-2 to the strains of the current pandemic, suggesting that the vast majority of nonsynonymous mutations currently segregating within the human strains have a negative impact on viral fitness. Finally, we estimate that the time to the most recent common ancestor of SARS-CoV-2 and RaTG13 or RmYN02 based on synonymous divergence is 51.71 years (95% CI, 28.11-75.31) and 37.02 years (95% CI, 18.19-55.85), respectively. äSynonymous mutations and the molecular evolution of SARS-CoV-2 origins(epmc).pdf DeepDyve Pubget Overpricing