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10.1128/JCM.02438-20

http://scihub22266oqcxt.onion/10.1128/JCM.02438-20
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33500361!8092720!33500361
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suck abstract from ncbi


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pmid33500361      J+Clin+Microbiol 2021 ; 59 (4): ä
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  • A New SARS-CoV-2 Dual-Purpose Serology Test: Highly Accurate Infection Tracing and Neutralizing Antibody Response Detection #MMPMID33500361
  • Taylor SC; Hurst B; Charlton CL; Bailey A; Kanji JN; McCarthy MK; Morrison TE; Huey L; Annen K; DomBourian MG; Knight V
  • J Clin Microbiol 2021[Mar]; 59 (4): ä PMID33500361show ga
  • Many severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) serology tests have proven to be less accurate than expected and do not assess antibody function as neutralizing, correlating with protection from reinfection. A new assay technology measuring the interaction of the purified SARS-CoV-2 spike protein receptor binding domain (RBD) with the extracellular domain of the human angiotensin-converting enzyme 2 (hACE2) receptor detects these important antibodies. The cPass surrogate virus neutralization test (sVNT), compared directly with eight SARS-CoV-2 IgG serology and two live-cell neutralization tests, gives similar or improved accuracy for qualitative delineation between positive and negative individuals in a fast, scalable, and high-throughput assay. The combined data support the cPass sVNT as a tool for highly accurate SARS-CoV-2 immunity surveillance of infected/recovered and/or vaccinated individuals as well as drug and convalescent-phase donor screening. The data also preview a novel application for the cPass sVNT in calibrating the stringency of live-cell neutralization tests and its use in longitudinal testing of recovered and/or vaccinated patients.
  • |*Antibodies, Neutralizing[MESH]
  • |*COVID-19[MESH]
  • |Antibodies, Viral[MESH]
  • |Humans[MESH]
  • |SARS-CoV-2[MESH]


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