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10.1016/j.celrep.2020.107725

http://scihub22266oqcxt.onion/10.1016/j.celrep.2020.107725
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33500101!ä!33500101

suck abstract from ncbi


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pmid33500101      Cell+Rep 2020 ; 31 (9): 107725
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  • Cross-reactive Antibody Response between SARS-CoV-2 and SARS-CoV Infections #MMPMID33500101
  • Lv H; Wu NC; Tsang OT; Yuan M; Perera RAPM; Leung WS; So RTY; Chan JMC; Yip GK; Chik TSH; Wang Y; Choi CYC; Lin Y; Ng WW; Zhao J; Poon LLM; Peiris JSM; Wilson IA; Mok CKP
  • Cell Rep 2020[Jun]; 31 (9): 107725 PMID33500101show ga
  • The World Health Organization has declared the ongoing outbreak of COVID-19, which is caused by a novel coronavirus SARS-CoV-2, a pandemic. There is currently a lack of knowledge about the antibody response elicited from SARS-CoV-2 infection. One major immunological question concerns antigenic differences between SARS-CoV-2 and SARS-CoV. We address this question by analyzing plasma from patients infected by SARS-CoV-2 or SARS-CoV and from infected or immunized mice. Our results show that, although cross-reactivity in antibody binding to the spike protein is common, cross-neutralization of the live viruses may be rare, indicating the presence of a non-neutralizing antibody response to conserved epitopes in the spike. Whether such low or non-neutralizing antibody response leads to antibody-dependent disease enhancement needs to be addressed in the future. Overall, this study not only addresses a fundamental question regarding antigenicity differences between SARS-CoV-2 and SARS-CoV but also has implications for immunogen design and vaccine development.
  • |*Antibody Formation[MESH]
  • |*Cross Reactions[MESH]
  • |*SARS-CoV-2[MESH]
  • |*Severe acute respiratory syndrome-related coronavirus[MESH]
  • |Animals[MESH]
  • |Antibodies, Neutralizing/immunology[MESH]
  • |Antibodies, Viral/immunology[MESH]
  • |Antigens/immunology[MESH]
  • |COVID-19 Serological Testing[MESH]
  • |COVID-19/blood/*immunology/virology[MESH]
  • |Chlorocebus aethiops[MESH]
  • |Epitopes/immunology[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Mice[MESH]
  • |Mice, Inbred BALB C[MESH]
  • |Neutralization Tests[MESH]
  • |Protein Binding[MESH]
  • |Protein Domains[MESH]
  • |Severe Acute Respiratory Syndrome/blood/*immunology/virology[MESH]
  • |Sf9 Cells[MESH]
  • |Spike Glycoprotein, Coronavirus/immunology[MESH]


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