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10.3390/ijms22031142 http://scihub22266oqcxt.onion/10.3390/ijms22031142 33498909!7865840!33498909     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Mol+Sci 2021 ; 22 (3): ä Nephropedia Template TP {{tp|p=33498909|t=2021. Membrane Microvesicles as Potential Vaccine Candidates |pdf=|usr=}}{{33498909}} gab.com Text Membrane Microvesicles as Potential Vaccine Candidates JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=33498909 #FOAvip The prevention and control of infectious diseases is crucial to the maintenance and protection of social and public healthcare. The global impact of SARS-CoV-2 has demonstrated how outbreaks of emerging and re-emerging infections can lead to pandemics of significant public health and socio-economic burden. Vaccination is one of the most effective approaches to protect against infectious diseases, and to date, multiple vaccines have been successfully used to protect against and eradicate both viral and bacterial pathogens. The main criterion of vaccine efficacy is the induction of specific humoral and cellular immune responses, and it is well established that immunogenicity depends on the type of vaccine as well as the route of delivery. In addition, antigen delivery to immune organs and the site of injection can potentiate efficacy of the vaccine. In light of this, microvesicles have been suggested as potential vehicles for antigen delivery as they can carry various immunogenic molecules including proteins, nucleic acids and polysaccharides directly to target cells. In this review, we focus on the mechanisms of microvesicle biogenesis and the role of microvesicles in infectious diseases. Further, we discuss the application of microvesicles as a novel and effective vaccine delivery system. Twit Text FOAVip Membrane Microvesicles as Potential Vaccine Candidates ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=33498909 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33498909 #FOAvip English Wikipedia <ref>{{Cite pmid|33498909}}</ref> Membrane Microvesicles as Potential Vaccine Candidates #MMPMID33498909 Shkair L; Garanina EE; Stott RJ; Foster TL; Rizvanov AA; Khaiboullina SF Int J Mol Sci 2021[Jan]; 22 (3): ä PMID33498909show ga The prevention and control of infectious diseases is crucial to the maintenance and protection of social and public healthcare. The global impact of SARS-CoV-2 has demonstrated how outbreaks of emerging and re-emerging infections can lead to pandemics of significant public health and socio-economic burden. Vaccination is one of the most effective approaches to protect against infectious diseases, and to date, multiple vaccines have been successfully used to protect against and eradicate both viral and bacterial pathogens. The main criterion of vaccine efficacy is the induction of specific humoral and cellular immune responses, and it is well established that immunogenicity depends on the type of vaccine as well as the route of delivery. In addition, antigen delivery to immune organs and the site of injection can potentiate efficacy of the vaccine. In light of this, microvesicles have been suggested as potential vehicles for antigen delivery as they can carry various immunogenic molecules including proteins, nucleic acids and polysaccharides directly to target cells. In this review, we focus on the mechanisms of microvesicle biogenesis and the role of microvesicles in infectious diseases. Further, we discuss the application of microvesicles as a novel and effective vaccine delivery system. |Animals[MESH] |COVID-19/immunology/*prevention & control[MESH] |Drug Delivery Systems/methods[MESH] |Extracellular Vesicles/*immunology[MESH] |Humans[MESH] |Immunologic Factors/*immunology[MESH] |SARS-CoV-2/*immunology[MESH] |Vaccination/methods[MESH]Membrane Microvesicles as Potential Vaccine Candidates (epmc).pdf DeepDyve Pubget Overpricing