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10.1016/j.cell.2021.01.007

http://scihub22266oqcxt.onion/10.1016/j.cell.2021.01.007
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33497610!7803150!33497610
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suck abstract from ncbi

pmid33497610      Cell 2021 ; 184 (4): 861-880
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  • Adaptive immunity to SARS-CoV-2 and COVID-19 #MMPMID33497610
  • Sette A; Crotty S
  • Cell 2021[Feb]; 184 (4): 861-880 PMID33497610show ga
  • The adaptive immune system is important for control of most viral infections. The three fundamental components of the adaptive immune system are B cells (the source of antibodies), CD4(+) T cells, and CD8(+) T cells. The armamentarium of B cells, CD4(+) T cells, and CD8(+) T cells has differing roles in different viral infections and in vaccines, and thus it is critical to directly study adaptive immunity to SARS-CoV-2 to understand COVID-19. Knowledge is now available on relationships between antigen-specific immune responses and SARS-CoV-2 infection. Although more studies are needed, a picture has begun to emerge that reveals that CD4(+) T cells, CD8(+) T cells, and neutralizing antibodies all contribute to control of SARS-CoV-2 in both non-hospitalized and hospitalized cases of COVID-19. The specific functions and kinetics of these adaptive immune responses are discussed, as well as their interplay with innate immunity and implications for COVID-19 vaccines and immune memory against re-infection.
  • |*Adaptive Immunity[MESH]
  • |Age Factors[MESH]
  • |B-Lymphocytes/immunology[MESH]
  • |COVID-19 Vaccines/immunology[MESH]
  • |COVID-19/complications/epidemiology/*immunology/pathology/virology[MESH]
  • |Clinical Trials as Topic[MESH]
  • |Humans[MESH]
  • |Immunologic Memory[MESH]
  • |Post-Acute COVID-19 Syndrome[MESH]
  • |Race Factors[MESH]
  • |SARS-CoV-2/classification/*physiology[MESH]
  • |Sex Factors[MESH]
  • |T-Lymphocyte Subsets/immunology[MESH]


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