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10.1111/ijcp.14047

http://scihub22266oqcxt.onion/10.1111/ijcp.14047
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33497517!7995195!33497517
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suck abstract from ncbi


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pmid33497517      Int+J+Clin+Pract 2021 ; 75 (7): e14047
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  • Eosinopenia is a reliable marker of severe disease and unfavourable outcome in patients with COVID-19 pneumonia #MMPMID33497517
  • Cazzaniga M; Fumagalli LAM; D'angelo L; Cerino M; Bonfanti G; Fumagalli RM; Schiavo G; Lorini C; Lainu E; Terragni S; Chiarelli M; Scarazzati C; Bonato C; Zago M
  • Int J Clin Pract 2021[Jul]; 75 (7): e14047 PMID33497517show ga
  • BACKGROUND AND AIM: Viral pneumonia is the most relevant clinical presentation of COVID-19 which may lead to severe acute respiratory syndrome and even death. Eosinopenia was often noticed in patients with COVID-19 pneumonia, but its role is poorly investigated. The aim of the present study was to investigate the characteristics and clinical outcomes of patients with COVID-19 pneumonia and eosinopenia. METHODS: We revised the records of consecutive patients with COVID-19 pneumonia admitted to our ER-COVID-19 area in order to compare clinical characteristics and outcomes of patients with and without eosinopenia. We considered the following clinical outcomes: 4-weeks survival; need for intensive respiratory support; and hospital discharge. RESULTS: Out of first 107 consecutive patients with pneumonia and a positive COVID-19 nasopharyngeal swab, 75 patients showed undetectable eosinophil count (absolute eosinopenia). At 4 weeks, 38 patients (38.4%) had required intensive respiratory treatment, 25 (23.4%) deceased and 42 (39.2%) were discharged. Compared with patients without absolute eosinopenia, patients with absolute eosinopenia showed higher need of intensive respiratory treatment (49.3% vs 13.3%, P < .001), higher mortality (30.6% vs 6.2%, P .006) and lower rate of hospital discharge (28% vs 65.6%, P < .001). Binary logistic regression analyses including neutrophil, lymphocyte, eosinophil, basophil and monocyte counts showed that absolute eosinopenia was an independent factor associated with 4-weeks mortality, need for intensive respiratory support and hospital discharge. CONCLUSIONS: Absolute eosinopenia is associated with clinical outcomes in patients with COVID-19 pneumonia and might be used as a marker to discriminate patients with unfavourable prognosis.
  • |*COVID-19[MESH]
  • |*Pneumonia, Viral[MESH]
  • |Eosinophils[MESH]
  • |Humans[MESH]
  • |Leukocyte Count[MESH]


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