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10.1172/jci.insight.144499 http://scihub22266oqcxt.onion/10.1172/jci.insight.144499 33497357!7934927!33497357     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       JCI+Insight 2021 ; 6 (4): ä Nephropedia Template TP {{tp|p=33497357|t=2021. Distinct antibody repertoires against endemic human coronaviruses in children and adults |pdf=|usr=}}{{33497357}} gab.com Text Distinct antibody repertoires against endemic human coronaviruses in children and adults JO: JCI Insight http://www.kidney.de/pget.php?&tw=1&pmid=33497357 #FOAvip Four endemic human coronaviruses (HCoVs) are commonly associated with acute respiratory infection in humans. B cell responses to these "common cold" viruses remain incompletely understood. Here we report a comprehensive analysis of CoV-specific antibody repertoires in 231 children and 1168 adults using phage immunoprecipitation sequencing. Seroprevalence of antibodies against endemic HCoVs ranged between approximately 4% and 27% depending on the species and cohort. We identified at least 136 novel linear B cell epitopes. Antibody repertoires against endemic HCoVs were qualitatively different between children and adults in that anti-HCoV IgG specificities more frequently found among children targeted functionally important and structurally conserved regions of the spike, nucleocapsid, and matrix proteins. Moreover, antibody specificities targeting the highly conserved fusion peptide region and S2' cleavage site of the spike protein were broadly cross-reactive with peptides of epidemic human and nonhuman coronaviruses. In contrast, an acidic tandem repeat in the N-terminal region of the Nsp3 subdomain of the HCoV-HKU1 polyprotein was the predominant target of antibody responses in adult donors. Our findings shed light on the dominant species-specific and pan-CoV target sites of human antibody responses to coronavirus infection, thereby providing important insights for the development of prophylactic or therapeutic monoclonal antibodies and vaccine design. Twit Text FOAVip Distinct antibody repertoires against endemic human coronaviruses in children and adults ????JCI Insight http://www.kidney.de/pget.php?&tw=1&pmid=33497357 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33497357 #FOAvip English Wikipedia <ref>{{Cite pmid|33497357}}</ref> Distinct antibody repertoires against endemic human coronaviruses in children and adults #MMPMID33497357 Khan T; Rahman M; Ali FA; Huang SSY; Ata M; Zhang Q; Bastard P; Liu Z; Jouanguy E; Beziat V; Cobat A; Nasrallah GK; Yassine HM; Smatti MK; Saeed A; Vandernoot I; Goffard JC; Smits G; Migeotte I; Haerynck F; Meyts I; Abel L; Casanova JL; Hasan MR; Marr N JCI Insight 2021[Feb]; 6 (4): ä PMID33497357show ga Four endemic human coronaviruses (HCoVs) are commonly associated with acute respiratory infection in humans. B cell responses to these "common cold" viruses remain incompletely understood. Here we report a comprehensive analysis of CoV-specific antibody repertoires in 231 children and 1168 adults using phage immunoprecipitation sequencing. Seroprevalence of antibodies against endemic HCoVs ranged between approximately 4% and 27% depending on the species and cohort. We identified at least 136 novel linear B cell epitopes. Antibody repertoires against endemic HCoVs were qualitatively different between children and adults in that anti-HCoV IgG specificities more frequently found among children targeted functionally important and structurally conserved regions of the spike, nucleocapsid, and matrix proteins. Moreover, antibody specificities targeting the highly conserved fusion peptide region and S2' cleavage site of the spike protein were broadly cross-reactive with peptides of epidemic human and nonhuman coronaviruses. In contrast, an acidic tandem repeat in the N-terminal region of the Nsp3 subdomain of the HCoV-HKU1 polyprotein was the predominant target of antibody responses in adult donors. Our findings shed light on the dominant species-specific and pan-CoV target sites of human antibody responses to coronavirus infection, thereby providing important insights for the development of prophylactic or therapeutic monoclonal antibodies and vaccine design. |*Endemic Diseases[MESH] |Adult[MESH] |Antibodies, Viral/blood/immunology/*isolation & purification[MESH] |Antibody Specificity[MESH] |Antigens, Viral/blood/immunology[MESH] |Child[MESH] |Child, Preschool[MESH] |Common Cold/blood/epidemiology/immunology/*virology[MESH] |Coronavirus Infections/blood/epidemiology/*immunology/virology[MESH] |Coronavirus/*immunology/isolation & purification[MESH] |Cross Reactions[MESH] |Epitopes, B-Lymphocyte/blood/immunology[MESH] |Female[MESH] |Humans[MESH] |Male[MESH] |Middle Aged[MESH] |Protein Domains/immunology[MESH] |Retrospective Studies[MESH] |Seroepidemiologic Studies[MESH]Distinct antibody repertoires against endemic human coronaviruses in c(epmc).pdf DeepDyve Pubget Overpricing