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10.1172/JCI144554 http://scihub22266oqcxt.onion/10.1172/JCI144554 33497356!7954607!33497356     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 298.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Clin+Invest 2021 ; 131 (6): ä Nephropedia Template TP {{tp|p=33497356|t=2021. Similarities and differences between the immunopathogenesis of COVID-19-related pediatric multisystem inflammatory syndrome and Kawasaki disease |pdf=|usr=}}{{33497356}} gab.com Text Similarities and differences between the immunopathogenesis of COVID-19-related pediatric multisystem inflammatory syndrome and Kawasaki disease JO: J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=33497356 #FOAvip Multisystem inflammatory syndrome associated with the SARS-CoV-2 pandemic has recently been described in children (MIS-C), partially overlapping with Kawasaki disease (KD). We hypothesized that (a) MIS-C and prepandemic KD cytokine profiles may be unique and justify the clinical differences observed, and (b) SARS-CoV-2-specific immune complexes (ICs) may explain the immunopathology of MIS-C. Seventy-four children were included: 14 with MIS-C, 9 patients positive for SARS-CoV-2 by PCR without MIS-C (COVID), 14 with prepandemic KD, and 37 healthy controls (HCs). Thirty-four circulating cytokines were quantified in pretreatment serum or plasma samples and the presence of circulating SARS-CoV-2 ICs was evaluated in MIS-C patients. Compared with HCs, the MIS-C and KD groups showed most cytokines to be significantly elevated, with IFN-gamma-induced response markers (including IFN-gamma, IL-18, and IP-10) and inflammatory monocyte activation markers (including MCP-1, IL-1alpha, and IL-1RA) being the main triggers of inflammation. In linear discriminant analysis, MIS-C and KD profiles overlapped; however, a subgroup of MIS-C patients (MIS-Cplus) differentiated from the remaining MIS-C patients in IFN-gamma, IL-18, GM-CSF, RANTES, IP-10, IL-1alpha, and SDF-1 and incipient signs of macrophage activation syndrome. Circulating SARS-CoV-2 ICs were not detected in MIS-C patients. Our findings suggest a major role for IFN-gamma in the pathogenesis of MIS-C, which may be relevant for therapeutic management. Twit Text FOAVip Similarities and differences between the immunopathogenesis of COVID-19-related pediatric multisystem inflammatory syndrome and Kawasaki disease ????J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=33497356 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33497356 #FOAvip English Wikipedia <ref>{{Cite pmid|33497356}}</ref> Similarities and differences between the immunopathogenesis of COVID-19-related pediatric multisystem inflammatory syndrome and Kawasaki disease #MMPMID33497356 Esteve-Sole A; Anton J; Pino-Ramirez RM; Sanchez-Manubens J; Fumado V; Fortuny C; Rios-Barnes M; Sanchez-de-Toledo J; Girona-Alarcon M; Mosquera JM; Ricart S; Launes C; de Sevilla MF; Jou C; Munoz-Almagro C; Gonzalez-Roca E; Vergara A; Carrillo J; Juan M; Cuadras D; Noguera-Julian A; Jordan I; Alsina L J Clin Invest 2021[Mar]; 131 (6): ä PMID33497356show ga Multisystem inflammatory syndrome associated with the SARS-CoV-2 pandemic has recently been described in children (MIS-C), partially overlapping with Kawasaki disease (KD). We hypothesized that (a) MIS-C and prepandemic KD cytokine profiles may be unique and justify the clinical differences observed, and (b) SARS-CoV-2-specific immune complexes (ICs) may explain the immunopathology of MIS-C. Seventy-four children were included: 14 with MIS-C, 9 patients positive for SARS-CoV-2 by PCR without MIS-C (COVID), 14 with prepandemic KD, and 37 healthy controls (HCs). Thirty-four circulating cytokines were quantified in pretreatment serum or plasma samples and the presence of circulating SARS-CoV-2 ICs was evaluated in MIS-C patients. Compared with HCs, the MIS-C and KD groups showed most cytokines to be significantly elevated, with IFN-gamma-induced response markers (including IFN-gamma, IL-18, and IP-10) and inflammatory monocyte activation markers (including MCP-1, IL-1alpha, and IL-1RA) being the main triggers of inflammation. In linear discriminant analysis, MIS-C and KD profiles overlapped; however, a subgroup of MIS-C patients (MIS-Cplus) differentiated from the remaining MIS-C patients in IFN-gamma, IL-18, GM-CSF, RANTES, IP-10, IL-1alpha, and SDF-1 and incipient signs of macrophage activation syndrome. Circulating SARS-CoV-2 ICs were not detected in MIS-C patients. Our findings suggest a major role for IFN-gamma in the pathogenesis of MIS-C, which may be relevant for therapeutic management. |Adolescent[MESH] |Antibodies, Viral/blood[MESH] |Antigen-Antibody Complex/blood[MESH] |Antigens, Viral/blood[MESH] |COVID-19/*etiology/immunology/virology[MESH] |Case-Control Studies[MESH] |Child[MESH] |Child, Preschool[MESH] |Cohort Studies[MESH] |Cross-Sectional Studies[MESH] |Cytokines/*blood[MESH] |Female[MESH] |Humans[MESH] |Infant[MESH] |Interferon-gamma/blood[MESH] |Male[MESH] |Models, Immunological[MESH] |Mucocutaneous Lymph Node Syndrome/*etiology/immunology[MESH] |Pandemics[MESH] |SARS-CoV-2/genetics/immunology[MESH]Similarities and differences between the immunopathogenesis of COVID-1(epmc).pdf DeepDyve Pubget Overpricing