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10.1016/j.heliyon.2021.e06033 http://scihub22266oqcxt.onion/10.1016/j.heliyon.2021.e06033 33495740!7817455!33495740     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Heliyon 2021 ; 7 (1): e06033 Nephropedia Template TP {{tp|p=33495740|t=2021. Phosphatidylserine is an overlooked mediator of COVID-19 thromboinflammation |pdf=|usr=}}{{33495740}} gab.com Text Phosphatidylserine is an overlooked mediator of COVID-19 thromboinflammation JO: Heliyon http://www.kidney.de/pget.php?&tw=1&pmid=33495740 #FOAvip A ubiquitous component of cell membrane, phosphatidylserine (PS), is likely to play a major, but as yet unrecognized, role in the thromboinflammation of COVID-19 and other critical illnesses. PS is present in all plasma membranes but is "hidden" on the inner surface by the action of an ATP-requiring enzyme. Failure of PS to be sequestered on the inner surface of cell membranes, release of PS-containing microparticles from cells, or shedding of enveloped viruses allows it to interact with extracellular proteins, including those of the coagulation and complement systems. Detection and quantification of circulating PS is not standardized, and current methodologies have either focused on circulating cellular elements or subcellular plasma components, but not both. PS may also promote thromboinflammation without circulating if expressed on the surface of endothelial cells, a condition that might only be documented if novel imaging techniques are developed. Research into the role of PS in inflammation and coagulation, called here a "procoagulant phospholipidopathy" may provide novel insights and therapeutic approaches for patients with a variety of illnesses. Twit Text FOAVip Phosphatidylserine is an overlooked mediator of COVID-19 thromboinflammation ????Heliyon http://www.kidney.de/pget.php?&tw=1&pmid=33495740 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33495740 #FOAvip English Wikipedia <ref>{{Cite pmid|33495740}}</ref> Phosphatidylserine is an overlooked mediator of COVID-19 thromboinflammation #MMPMID33495740 Lind SE Heliyon 2021[Jan]; 7 (1): e06033 PMID33495740show ga A ubiquitous component of cell membrane, phosphatidylserine (PS), is likely to play a major, but as yet unrecognized, role in the thromboinflammation of COVID-19 and other critical illnesses. PS is present in all plasma membranes but is "hidden" on the inner surface by the action of an ATP-requiring enzyme. Failure of PS to be sequestered on the inner surface of cell membranes, release of PS-containing microparticles from cells, or shedding of enveloped viruses allows it to interact with extracellular proteins, including those of the coagulation and complement systems. Detection and quantification of circulating PS is not standardized, and current methodologies have either focused on circulating cellular elements or subcellular plasma components, but not both. PS may also promote thromboinflammation without circulating if expressed on the surface of endothelial cells, a condition that might only be documented if novel imaging techniques are developed. Research into the role of PS in inflammation and coagulation, called here a "procoagulant phospholipidopathy" may provide novel insights and therapeutic approaches for patients with a variety of illnesses. äPhosphatidylserine is an overlooked mediator of COVID-19 thromboinflam(epmc).pdf DeepDyve Pubget Overpricing