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10.1016/j.scib.2021.01.010 http://scihub22266oqcxt.onion/10.1016/j.scib.2021.01.010 33495714!7816574!33495714     free     free     free       Sci+Bull+(Beijing) 2021 ; 66 (12): 1205-1214 Nephropedia Template TP {{tp|p=33495714|t=2021. Binding of the SARS-CoV-2 spike protein to glycans |pdf=|usr=}}{{33495714}} gab.com Text Binding of the SARS-CoV-2 spike protein to glycans JO: Sci Bull (Beijing) http://www.kidney.de/pget.php?&tw=1&pmid=33495714 #FOAvip The pandemic of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a high number of deaths in the world. To combat it, it is necessary to develop a better understanding of how the virus infects host cells. Infection normally starts with the attachment of the virus to cell-surface glycans like heparan sulfate (HS) and sialic acid-containing glycolipids/glycoproteins. In this study, we examined and compared the binding of the subunits and spike (S) proteins of SARS-CoV-2, SARS-CoV, and Middle East respiratory disease (MERS)-CoV to these glycans. Our results revealed that the S proteins and subunits can bind to HS in a sulfation-dependent manner and no binding with sialic acid residues was detected. Overall, this work suggests that HS binding may be a general mechanism for the attachment of these coronaviruses to host cells, and supports the potential importance of HS in infection and in the development of antiviral agents against these viruses. Twit Text FOAVip Binding of the SARS-CoV-2 spike protein to glycans ????Sci Bull (Beijing) http://www.kidney.de/pget.php?&tw=1&pmid=33495714 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33495714 #FOAvip English Wikipedia <ref>{{Cite pmid|33495714}}</ref> Binding of the SARS-CoV-2 spike protein to glycans #MMPMID33495714 Hao W; Ma B; Li Z; Wang X; Gao X; Li Y; Qin B; Shang S; Cui S; Tan Z Sci Bull (Beijing) 2021[Jun]; 66 (12): 1205-1214 PMID33495714show ga The pandemic of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a high number of deaths in the world. To combat it, it is necessary to develop a better understanding of how the virus infects host cells. Infection normally starts with the attachment of the virus to cell-surface glycans like heparan sulfate (HS) and sialic acid-containing glycolipids/glycoproteins. In this study, we examined and compared the binding of the subunits and spike (S) proteins of SARS-CoV-2, SARS-CoV, and Middle East respiratory disease (MERS)-CoV to these glycans. Our results revealed that the S proteins and subunits can bind to HS in a sulfation-dependent manner and no binding with sialic acid residues was detected. Overall, this work suggests that HS binding may be a general mechanism for the attachment of these coronaviruses to host cells, and supports the potential importance of HS in infection and in the development of antiviral agents against these viruses. äBinding of the SARS-CoV-2 spike protein to glycans (epmc).pdf DeepDyve Pubget Overpricing