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10.1126/science.abf9302 http://scihub22266oqcxt.onion/10.1126/science.abf9302 33495308!7963219!33495308     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Science 2021 ; 371 (6531): 850-854 Nephropedia Template TP {{tp|p=33495308|t=2021. Prospective mapping of viral mutations that escape antibodies used to treat COVID-19 |pdf=|usr=}}{{33495308}} gab.com Text Prospective mapping of viral mutations that escape antibodies used to treat COVID-19 JO: Science http://www.kidney.de/pget.php?&tw=1&pmid=33495308 #FOAvip Antibodies are a potential therapy for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), but the risk of the virus evolving to escape them remains unclear. Here we map how all mutations to the receptor binding domain (RBD) of SARS-CoV-2 affect binding by the antibodies in the REGN-COV2 cocktail and the antibody LY-CoV016. These complete maps uncover a single amino acid mutation that fully escapes the REGN-COV2 cocktail, which consists of two antibodies, REGN10933 and REGN10987, targeting distinct structural epitopes. The maps also identify viral mutations that are selected in a persistently infected patient treated with REGN-COV2 and during in vitro viral escape selections. Finally, the maps reveal that mutations escaping the individual antibodies are already present in circulating SARS-CoV-2 strains. These complete escape maps enable interpretation of the consequences of mutations observed during viral surveillance. Twit Text FOAVip Prospective mapping of viral mutations that escape antibodies used to treat COVID-19 ????Science http://www.kidney.de/pget.php?&tw=1&pmid=33495308 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33495308 #FOAvip English Wikipedia <ref>{{Cite pmid|33495308}}</ref> Prospective mapping of viral mutations that escape antibodies used to treat COVID-19 #MMPMID33495308 Starr TN; Greaney AJ; Addetia A; Hannon WW; Choudhary MC; Dingens AS; Li JZ; Bloom JD Science 2021[Feb]; 371 (6531): 850-854 PMID33495308show ga Antibodies are a potential therapy for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), but the risk of the virus evolving to escape them remains unclear. Here we map how all mutations to the receptor binding domain (RBD) of SARS-CoV-2 affect binding by the antibodies in the REGN-COV2 cocktail and the antibody LY-CoV016. These complete maps uncover a single amino acid mutation that fully escapes the REGN-COV2 cocktail, which consists of two antibodies, REGN10933 and REGN10987, targeting distinct structural epitopes. The maps also identify viral mutations that are selected in a persistently infected patient treated with REGN-COV2 and during in vitro viral escape selections. Finally, the maps reveal that mutations escaping the individual antibodies are already present in circulating SARS-CoV-2 strains. These complete escape maps enable interpretation of the consequences of mutations observed during viral surveillance. |*Mutation[MESH] |Amino Acid Substitution[MESH] |Angiotensin-Converting Enzyme 2/metabolism[MESH] |Antibodies, Monoclonal, Humanized/*immunology/metabolism/therapeutic use[MESH] |Antibodies, Viral/*immunology/metabolism/therapeutic use[MESH] |COVID-19 Serotherapy[MESH] |COVID-19/*therapy[MESH] |Cells, Cultured[MESH] |Drug Combinations[MESH] |Humans[MESH] |Immunization, Passive[MESH] |Protein Binding[MESH] |Protein Domains[MESH] |Receptors, Coronavirus/metabolism[MESH] |SARS-CoV-2/*genetics/*immunology[MESH]Prospective mapping of viral mutations that escape antibodies used to (epmc).pdf DeepDyve Pubget Overpricing