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10.1038/s41586-021-03234-7 http://scihub22266oqcxt.onion/10.1038/s41586-021-03234-7 33494096!8567458!33494096     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nature 2021 ; 591 (7848): 124-130 Nephropedia Template TP {{tp|p=33494096|t=2021. Global absence and targeting of protective immune states in severe COVID-19 |pdf=|usr=}}{{33494096}} gab.com Text Global absence and targeting of protective immune states in severe COVID-19 JO: Nature http://www.kidney.de/pget.php?&tw=1&pmid=33494096 #FOAvip Although infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has pleiotropic and systemic effects in some individuals(1-3), many others experience milder symptoms. Here, to gain a more comprehensive understanding of the distinction between severe and mild phenotypes in the pathology of coronavirus disease 2019 (COVID-19) and its origins, we performed a whole-blood-preserving single-cell analysis protocol to integrate contributions from all major immune cell types of the blood-including neutrophils, monocytes, platelets, lymphocytes and the contents of the serum. Patients with mild COVID-19 exhibit a coordinated pattern of expression of interferon-stimulated genes (ISGs)(3) across every cell population, whereas these ISG-expressing cells are systemically absent in patients with severe disease. Paradoxically, individuals with severe COVID-19 produce very high titres of anti-SARS-CoV-2 antibodies and have a lower viral load compared to individuals with mild disease. Examination of the serum from patients with severe COVID-19 shows that these patients uniquely produce antibodies that functionally block the production of the ISG-expressing cells associated with mild disease, by activating conserved signalling circuits that dampen cellular responses to interferons. Overzealous antibody responses pit the immune system against itself in many patients with COVID-19, and perhaps also in individuals with other viral infections. Our findings reveal potential targets for immunotherapies in patients with severe COVID-19 to re-engage viral defence. Twit Text FOAVip Global absence and targeting of protective immune states in severe COVID-19 ????Nature http://www.kidney.de/pget.php?&tw=1&pmid=33494096 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33494096 #FOAvip English Wikipedia <ref>{{Cite pmid|33494096}}</ref> Global absence and targeting of protective immune states in severe COVID-19 #MMPMID33494096 Combes AJ; Courau T; Kuhn NF; Hu KH; Ray A; Chen WS; Chew NW; Cleary SJ; Kushnoor D; Reeder GC; Shen A; Tsui J; Hiam-Galvez KJ; Munoz-Sandoval P; Zhu WS; Lee DS; Sun Y; You R; Magnen M; Rodriguez L; Im KW; Serwas NK; Leligdowicz A; Zamecnik CR; Loudermilk RP; Wilson MR; Ye CJ; Fragiadakis GK; Looney MR; Chan V; Ward A; Carrillo S; Matthay M; Erle DJ; Woodruff PG; Langelier C; Kangelaris K; Hendrickson CM; Calfee C; Rao AA; Krummel MF Nature 2021[Mar]; 591 (7848): 124-130 PMID33494096show ga Although infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has pleiotropic and systemic effects in some individuals(1-3), many others experience milder symptoms. Here, to gain a more comprehensive understanding of the distinction between severe and mild phenotypes in the pathology of coronavirus disease 2019 (COVID-19) and its origins, we performed a whole-blood-preserving single-cell analysis protocol to integrate contributions from all major immune cell types of the blood-including neutrophils, monocytes, platelets, lymphocytes and the contents of the serum. Patients with mild COVID-19 exhibit a coordinated pattern of expression of interferon-stimulated genes (ISGs)(3) across every cell population, whereas these ISG-expressing cells are systemically absent in patients with severe disease. Paradoxically, individuals with severe COVID-19 produce very high titres of anti-SARS-CoV-2 antibodies and have a lower viral load compared to individuals with mild disease. Examination of the serum from patients with severe COVID-19 shows that these patients uniquely produce antibodies that functionally block the production of the ISG-expressing cells associated with mild disease, by activating conserved signalling circuits that dampen cellular responses to interferons. Overzealous antibody responses pit the immune system against itself in many patients with COVID-19, and perhaps also in individuals with other viral infections. Our findings reveal potential targets for immunotherapies in patients with severe COVID-19 to re-engage viral defence. |Antibodies, Viral/blood/*immunology[MESH] |Antibody Formation[MESH] |Base Sequence[MESH] |COVID-19/blood/*immunology/*physiopathology/virology[MESH] |Female[MESH] |Humans[MESH] |Immunoglobulin G/immunology[MESH] |Interferons/*antagonists & inhibitors/*immunology/metabolism[MESH] |Male[MESH] |Neutrophils/immunology/pathology[MESH] |Protein Domains[MESH] |Receptor, Interferon alpha-beta/antagonists & inhibitors/immunology/metabolism[MESH] |Receptors, IgG/immunology[MESH] |SARS-CoV-2/*immunology/*pathogenicity[MESH] |Single-Cell Analysis[MESH]Global absence and targeting of protective immune states in severe COV(epmc).pdf DeepDyve Pubget Overpricing