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10.1093/jmcb/mjab003 http://scihub22266oqcxt.onion/10.1093/jmcb/mjab003 33493263!7928767!33493263     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Mol+Cell+Biol 2021 ; 13 (3): 185-196 Nephropedia Template TP {{tp|p=33493263|t=2021. Kidney injury molecule-1 is a potential receptor for SARS-CoV-2 |pdf=|usr=}}{{33493263}} gab.com Text Kidney injury molecule-1 is a potential receptor for SARS-CoV-2 JO: J Mol Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=33493263 #FOAvip COVID-19 patients present high incidence of kidney abnormalities, which are associated with poor prognosis and mortality. The identification of SARS-CoV-2 in the kidney of COVID-19 patients suggests renal tropism of SARS-CoV-2. However, whether there is a specific target of SARS-CoV-2 in the kidney remains unclear. Herein, by using in silico simulation, coimmunoprecipitation, fluorescence resonance energy transfer, fluorescein isothiocyanate labeling, and rational design of antagonist peptides, we demonstrate that kidney injury molecule-1 (KIM1), a molecule dramatically upregulated upon kidney injury, binds with the receptor-binding domain (RBD) of SARS-CoV-2 and facilitates its attachment to cell membrane, with the immunoglobulin variable Ig-like (Ig V) domain of KIM1 playing a key role in this recognition. The interaction between SARS-CoV-2 RBD and KIM1 is potently blockaded by a rationally designed KIM1-derived polypeptide AP2. In addition, our results also suggest interactions between KIM1 Ig V domain and the RBDs of SARS-CoV and MERS-CoV, pathogens of two severe infectious respiratory diseases. Together, these findings suggest KIM1 as a novel receptor for SARS-CoV-2 and other coronaviruses. We propose that KIM1 may thus mediate and exacerbate the renal infection of SARS-CoV-2 in a 'vicious cycle', and KIM1 could be further explored as a therapeutic target. Twit Text FOAVip Kidney injury molecule-1 is a potential receptor for SARS-CoV-2 ????J Mol Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=33493263 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33493263 #FOAvip English Wikipedia <ref>{{Cite pmid|33493263}}</ref> Kidney injury molecule-1 is a potential receptor for SARS-CoV-2 #MMPMID33493263 Yang C; Zhang Y; Zeng X; Chen H; Chen Y; Yang D; Shen Z; Wang X; Liu X; Xiong M; Chen H; Huang K J Mol Cell Biol 2021[Jul]; 13 (3): 185-196 PMID33493263show ga COVID-19 patients present high incidence of kidney abnormalities, which are associated with poor prognosis and mortality. The identification of SARS-CoV-2 in the kidney of COVID-19 patients suggests renal tropism of SARS-CoV-2. However, whether there is a specific target of SARS-CoV-2 in the kidney remains unclear. Herein, by using in silico simulation, coimmunoprecipitation, fluorescence resonance energy transfer, fluorescein isothiocyanate labeling, and rational design of antagonist peptides, we demonstrate that kidney injury molecule-1 (KIM1), a molecule dramatically upregulated upon kidney injury, binds with the receptor-binding domain (RBD) of SARS-CoV-2 and facilitates its attachment to cell membrane, with the immunoglobulin variable Ig-like (Ig V) domain of KIM1 playing a key role in this recognition. The interaction between SARS-CoV-2 RBD and KIM1 is potently blockaded by a rationally designed KIM1-derived polypeptide AP2. In addition, our results also suggest interactions between KIM1 Ig V domain and the RBDs of SARS-CoV and MERS-CoV, pathogens of two severe infectious respiratory diseases. Together, these findings suggest KIM1 as a novel receptor for SARS-CoV-2 and other coronaviruses. We propose that KIM1 may thus mediate and exacerbate the renal infection of SARS-CoV-2 in a 'vicious cycle', and KIM1 could be further explored as a therapeutic target. |COVID-19/*genetics/pathology/virology[MESH] |Computer Simulation[MESH] |Hepatitis A Virus Cellular Receptor 1/*genetics[MESH] |Humans[MESH] |Kidney/pathology/virology[MESH] |Protein Binding/genetics[MESH] |Receptors, Virus/*genetics[MESH]Kidney injury molecule-1 is a potential receptor for SARS-CoV-2 (epmc).pdf DeepDyve Pubget Overpricing