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Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Arch+Virol 2021 ; 166 (3): 935-941 Nephropedia Template TP
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Replicative capacity of four porcine enteric coronaviruses in LLC-PK1 cells #MMPMID33492525
Xiao W; Wang X; Wang J; Fang P; Xiao S; Fang L
Arch Virol 2021[Mar]; 166 (3): 935-941 PMID33492525show ga
Enteric coronaviruses (CoVs) are major pathogens that cause diarrhea in piglets. To date, four porcine enteric CoVs have been identified: transmissible gastroenteritis virus (TGEV), porcine epidemic diarrhea virus (PEDV), porcine deltacoronavirus (PDCoV), and HKU2-like porcine enteric alphacoronavirus (PEAV). In this study, we investigated the replicative capacity of these four enteric CoVs in LLC-PK1 cells, a porcine kidney cell line. The results showed that LLC-PK1 cells are susceptible to all four enteric CoVs, particularly to TGEV and PDCoV infections, indicating that LLC-PK1 cells can be applied to porcine enteric CoV research in vitro, particularly for coinfection studies.
|Animals[MESH]
|Cell Line[MESH]
|Chlorocebus aethiops[MESH]
|Deltacoronavirus/*growth & development[MESH]
|Disease Susceptibility[MESH]
|Fluorescent Antibody Technique, Indirect[MESH]
|Gastroenteritis, Transmissible, of Swine/*virology[MESH]