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10.1080/14756366.2021.1873977 http://scihub22266oqcxt.onion/10.1080/14756366.2021.1873977 33491508!7850424!33491508     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Enzyme+Inhib+Med+Chem 2021 ; 36 (1): 497-503 Nephropedia Template TP {{tp|p=33491508|t=2021. Scutellaria baicalensis extract and baicalein inhibit replication of SARS-CoV-2 and its 3C-like protease in vitro |pdf=|usr=}}{{33491508}} gab.com Text Scutellaria baicalensis extract and baicalein inhibit replication of SARS-CoV-2 and its 3C-like protease in vitro JO: J Enzyme Inhib Med Chem http://www.kidney.de/pget.php?&tw=1&pmid=33491508 #FOAvip COVID-19 has become a global pandemic and there is an urgent call for developing drugs against the virus (SARS-CoV-2). The 3C-like protease (3CL(pro)) of SARS-CoV-2 is a preferred target for broad spectrum anti-coronavirus drug discovery. We studied the anti-SARS-CoV-2 activity of S. baicalensis and its ingredients. We found that the ethanol extract of S. baicalensis and its major component, baicalein, inhibit SARS-CoV-2 3CL(pro) activity in vitro with IC(50)'s of 8.52 microg/ml and 0.39 microM, respectively. Both of them inhibit the replication of SARS-CoV-2 in Vero cells with EC(50)'s of 0.74 microg/ml and 2.9 microM, respectively. While baicalein is mainly active at the viral post-entry stage, the ethanol extract also inhibits viral entry. We further identified four baicalein analogues from other herbs that inhibit SARS-CoV-2 3CL(pro) activity at microM concentration. All the active compounds and the S. baicalensis extract also inhibit the SARS-CoV 3CL(pro), demonstrating their potential as broad-spectrum anti-coronavirus drugs. Twit Text FOAVip Scutellaria baicalensis extract and baicalein inhibit replication of SARS-CoV-2 and its 3C-like protease in vitro ????J Enzyme Inhib Med Chem http://www.kidney.de/pget.php?&tw=1&pmid=33491508 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33491508 #FOAvip English Wikipedia <ref>{{Cite pmid|33491508}}</ref> Scutellaria baicalensis extract and baicalein inhibit replication of SARS-CoV-2 and its 3C-like protease in vitro #MMPMID33491508 Liu H; Ye F; Sun Q; Liang H; Li C; Li S; Lu R; Huang B; Tan W; Lai L J Enzyme Inhib Med Chem 2021[Dec]; 36 (1): 497-503 PMID33491508show ga COVID-19 has become a global pandemic and there is an urgent call for developing drugs against the virus (SARS-CoV-2). The 3C-like protease (3CL(pro)) of SARS-CoV-2 is a preferred target for broad spectrum anti-coronavirus drug discovery. We studied the anti-SARS-CoV-2 activity of S. baicalensis and its ingredients. We found that the ethanol extract of S. baicalensis and its major component, baicalein, inhibit SARS-CoV-2 3CL(pro) activity in vitro with IC(50)'s of 8.52 microg/ml and 0.39 microM, respectively. Both of them inhibit the replication of SARS-CoV-2 in Vero cells with EC(50)'s of 0.74 microg/ml and 2.9 microM, respectively. While baicalein is mainly active at the viral post-entry stage, the ethanol extract also inhibits viral entry. We further identified four baicalein analogues from other herbs that inhibit SARS-CoV-2 3CL(pro) activity at microM concentration. All the active compounds and the S. baicalensis extract also inhibit the SARS-CoV 3CL(pro), demonstrating their potential as broad-spectrum anti-coronavirus drugs. |*COVID-19 Drug Treatment[MESH] |Animals[MESH] |Antiviral Agents/*pharmacology[MESH] |COVID-19/enzymology/virology[MESH] |Chlorocebus aethiops[MESH] |Coronavirus 3C Proteases/*antagonists & inhibitors[MESH] |Drug Discovery[MESH] |Enzyme Inhibitors/pharmacology[MESH] |Flavanones/*pharmacology[MESH] |Humans[MESH] |In Vitro Techniques[MESH] |Models, Molecular[MESH] |Plant Extracts/*pharmacology[MESH] |Protease Inhibitors/*pharmacology[MESH] |SARS-CoV-2/*drug effects/enzymology[MESH] |Scutellaria baicalensis[MESH] |Vero Cells[MESH]Scutellaria baicalensis extract and baicalein inhibit replication of S(epmc).pdf DeepDyve Pubget Overpricing