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Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 J+Nutr+Health+Aging 2021 ; 25 (2): 189-196 Nephropedia Template TP
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Impact of Serum 25(OH) Vitamin D Level on Mortality in Patients with COVID-19 in Turkey #MMPMID33491033
Karahan S; Katkat F
J Nutr Health Aging 2021[]; 25 (2): 189-196 PMID33491033show ga
BACKGROUND: Because of the lack of sufficient data, we aimed to investigate the role of serum 25(OH) vitamin D level on COVID severity and related mortality. METHODS: This was a retrospective observational study. Data, including sociodemographic features, clinical characteristics, and laboratory data, and 25(OH) vitamin D levels were recorded for each study participant. Patients were stratified into different vitamin D groups; Normal (Serum 25(OH) vitamin D level >30 ng/mL), Vitamin D insufficiency (21-29 ng/mL), and deficiency (<20 ng/mL). The severity of COVID was classified according to the Chinese Clinical Guideline for classification of COVID-19 severity. Mortality data were determined for participants. Univariate and multivariate Logistic regression analysis was performed to determine independent predictors of in-hospital mortality. RESULTS: Overall, 149 COVID-19 patients (females 45.6%, mean age 63.5 +/- 15.3 (range 24-90 years) years) were included. Forty-seven patients (31.5%) had moderate COVID-19, whereas 102 patients (68.5%) had severe-critical COVID-19. The mean 25(OH) vitamin D level was 15.2 +/- 10.3 ng/mL. Thirty-four (22.8%) and 103 (69.1%) patients had vitamin D insufficiency and deficiency, respectively. Mean serum 25(OH) vitamin D level was significantly lower in patients with severe-critical COVID-19 compared with moderate COVID-19 (10.1 +/- 6.2 vs. 26.3 +/- 8.4 ng/mL, respectively, p<0.001). Vitamin D insufficiency was present in 93.1% of the patients with severe-critical COVID-19. Multivariate logistic regression analysis revealed that only lymphocyte count, white blood cell count, serum albumin and, 25(OH) vitamin D level were independent predictors of mortality. CONCLUSION: Serum 25(OH) vitamin D was independently associated with mortality in COVID-19 patients.
|Adult[MESH]
|Aged[MESH]
|Aged, 80 and over[MESH]
|COVID-19 Drug Treatment[MESH]
|COVID-19/*blood/*mortality/virology[MESH]
|Female[MESH]
|Humans[MESH]
|Logistic Models[MESH]
|Male[MESH]
|Middle Aged[MESH]
|Pandemics[MESH]
|Retrospective Studies[MESH]
|SARS-CoV-2/isolation & purification[MESH]
|Turkey/epidemiology[MESH]
|Vitamin D Deficiency/*blood/mortality/virology[MESH]
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J+Nutr+Health+Aging 2021 ; 25 (2): 189-196
