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10.1016/j.genrep.2021.101024 http://scihub22266oqcxt.onion/10.1016/j.genrep.2021.101024 33490718!7813478!33490718     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Gene+Rep 2021 ; 23 (ä): 101024 Nephropedia Template TP {{tp|p=33490718|t=2021. Mutational analysis of SARS-CoV-2 ORF8 during six months of COVID-19 pandemic |pdf=|usr=}}{{33490718}} gab.com Text Mutational analysis of SARS-CoV-2 ORF8 during six months of COVID-19 pandemic JO: Gene Rep http://www.kidney.de/pget.php?&tw=1&pmid=33490718 #FOAvip SARS-CoV-2, the causal agent of COVID 19, is a new human pathogen that appeared in Wuhan, late December 2019. SARS-CoV-2 is a positive sense RNA virus, having four structural and six accessory proteins including that encoded by ORF8 gene known to be one of the most hypervariable and rapidly evolving genes. Thus, global characterization of mutations in this gene is important for pathogenicity and diagnostics. 240 different nonsynonymous mutations and 2 deletions were identified in 45,400 ORF8 nucleotide sequences during six months pandemic with about half of these variants were deleterious for ORF8, and the quarter of them were located in conserved amino acids. Genetic diversity analysis showed two main regions that harbor L84S and S24L. L84S is by far the most predominant mutation, followed by S24L that appeared first in USA. Phylogenetic analysis of ORF8 variants revealed the appearance of small clades with that of L84S being closer to bats. This is the first study that revealed the global nonsynonymous mutations in ORF8 from January to June 2020. Twit Text FOAVip Mutational analysis of SARS-CoV-2 ORF8 during six months of COVID-19 pandemic ????Gene Rep http://www.kidney.de/pget.php?&tw=1&pmid=33490718 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33490718 #FOAvip English Wikipedia <ref>{{Cite pmid|33490718}}</ref> Mutational analysis of SARS-CoV-2 ORF8 during six months of COVID-19 pandemic #MMPMID33490718 Alkhansa A; Lakkis G; El Zein L Gene Rep 2021[Jun]; 23 (ä): 101024 PMID33490718show ga SARS-CoV-2, the causal agent of COVID 19, is a new human pathogen that appeared in Wuhan, late December 2019. SARS-CoV-2 is a positive sense RNA virus, having four structural and six accessory proteins including that encoded by ORF8 gene known to be one of the most hypervariable and rapidly evolving genes. Thus, global characterization of mutations in this gene is important for pathogenicity and diagnostics. 240 different nonsynonymous mutations and 2 deletions were identified in 45,400 ORF8 nucleotide sequences during six months pandemic with about half of these variants were deleterious for ORF8, and the quarter of them were located in conserved amino acids. Genetic diversity analysis showed two main regions that harbor L84S and S24L. L84S is by far the most predominant mutation, followed by S24L that appeared first in USA. Phylogenetic analysis of ORF8 variants revealed the appearance of small clades with that of L84S being closer to bats. This is the first study that revealed the global nonsynonymous mutations in ORF8 from January to June 2020. äMutational analysis of SARS-CoV-2 ORF8 during six months of COVID-19 p(epmc).pdf DeepDyve Pubget Overpricing