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10.1016/j.amsu.2020.12.051

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33489115!7806502!33489115
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suck abstract from ncbi


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pmid33489115      Ann+Med+Surg+(Lond) 2021 ; 62 (ä): 43-48
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  • Remdesivir therapy in patients with COVID-19: A systematic review and meta-analysis of randomized controlled trials #MMPMID33489115
  • Reddy Vegivinti CT; Pederson JM; Saravu K; Gupta N; Barrett A; Davis AR; Kallmes KM; Evanson KW
  • Ann Med Surg (Lond) 2021[Feb]; 62 (ä): 43-48 PMID33489115show ga
  • PURPOSE: To perform a systematic review and meta-analysis of randomized controlled trials that examined remdesivir treatment for COVID-19. MATERIALS AND METHODS: A systematic literature search was performed using Pubmed, Embase, and ClinicalTrials.gov to identify studies published up to October 25, 2020 that examined COVID-19 treatment with remdesivir. A total of 3 randomized controlled trials that consisted of 1691 patients were included in the meta-analysis. RESULTS: The odds for mechanical ventilation (MV) or extracorporeal membrane oxygenation (ECMO) following treatment was significantly lower in the remdesivir group compared to the control group (OR = 0.48 [95% CI: 0.34; 0.69], p < 0.001). The odds of early (at day 14/15; OR = 1.42 [95% CI: 1.16; 1.74], p < 0.001) and late (at day 28/29; OR = 1.44 [95% CI: 1.16; 1.79], p = 0.001) hospital discharge were significantly higher in the remdesivir group compared to the control group. There was no difference in the odds for mortality in patients treated with remdesivir (OR = 0.77 [95% CI: 0.56; 1.06], p = 0.108). CONCLUSIONS: Remdesivir attenuates disease progression, leading to lower odds of MV/ECMO and greater odds of hospital discharge for COVID-19 patients. However, remdesivir does not affect odds of mortality.
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