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10.3389/fendo.2020.593179 http://scihub22266oqcxt.onion/10.3389/fendo.2020.593179 33488517!7820749!33488517     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Endocrinol+(Lausanne) 2020 ; 11 (ä): 593179 Nephropedia Template TP {{tp|p=33488517|t=2020. The Adrenal Cortex, an Underestimated Site of SARS-CoV-2 Infection |pdf=|usr=}}{{33488517}} gab.com Text The Adrenal Cortex, an Underestimated Site of SARS-CoV-2 Infection JO: Front Endocrinol (Lausanne) http://www.kidney.de/pget.php?&tw=1&pmid=33488517 #FOAvip BACKGROUND: The majority of the critically ill patients may have critical illness-related corticosteroid insufficiency (CIRCI). The therapeutic effect of dexamethasone may be related to its ability to improve cortical function. Recent study showed that dexamethasone can reduce COVID-19 deaths by up to one third in critically ill patients. The aim of this article is to investigate whether SARS-CoV-2 can attack the adrenal cortex to aggravate the relative adrenal insufficiency. METHODS: We summarized the clinical features of COVID-19 reported in currently available observational studies. ACE2 and TMPRSS2 expression was examined in human adrenal glands by immunohistochemical staining. We retrospectively analyzed serum cortisol levels in critically ill patients with or without COVID-19. RESULTS: High percentage of critically ill patients with SARS-COV-2 infection in the study were treated with vasopressors. ACE2 receptor and TMPRSS2 serine protease were colocalized in adrenocortical cells in zona fasciculata and zona reticularis. We collected plasma cortisol concentrations in nine critically ill patients with COVID-19. The cortisol levels of critically ill patients with COVID-19 were lower than those in non-COVID-19 critically ill group. Six of the nine COVID-19 critically ill patients had random plasma cortisol concentrations below 10 microg/dl, which met the criteria for the diagnosis of CIRCI. CONCLUSION: We demonstrate that ACE2 and TMPRSS2 are colocalized in adrenocortical cells, and that the cortisol levels are lower in critically ill patients with COVID-19 as compared to those of non-COVID-19 critically ill patients. Based on our findings, we recommend measuring plasma cortisol level to guide hormonal therapy. Twit Text FOAVip The Adrenal Cortex, an Underestimated Site of SARS-CoV-2 Infection ????Front Endocrinol (Lausanne) http://www.kidney.de/pget.php?&tw=1&pmid=33488517 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33488517 #FOAvip English Wikipedia <ref>{{Cite pmid|33488517}}</ref> The Adrenal Cortex, an Underestimated Site of SARS-CoV-2 Infection #MMPMID33488517 Mao Y; Xu B; Guan W; Xu D; Li F; Ren R; Zhu X; Gao Y; Jiang L Front Endocrinol (Lausanne) 2020[]; 11 (ä): 593179 PMID33488517show ga BACKGROUND: The majority of the critically ill patients may have critical illness-related corticosteroid insufficiency (CIRCI). The therapeutic effect of dexamethasone may be related to its ability to improve cortical function. Recent study showed that dexamethasone can reduce COVID-19 deaths by up to one third in critically ill patients. The aim of this article is to investigate whether SARS-CoV-2 can attack the adrenal cortex to aggravate the relative adrenal insufficiency. METHODS: We summarized the clinical features of COVID-19 reported in currently available observational studies. ACE2 and TMPRSS2 expression was examined in human adrenal glands by immunohistochemical staining. We retrospectively analyzed serum cortisol levels in critically ill patients with or without COVID-19. RESULTS: High percentage of critically ill patients with SARS-COV-2 infection in the study were treated with vasopressors. ACE2 receptor and TMPRSS2 serine protease were colocalized in adrenocortical cells in zona fasciculata and zona reticularis. We collected plasma cortisol concentrations in nine critically ill patients with COVID-19. The cortisol levels of critically ill patients with COVID-19 were lower than those in non-COVID-19 critically ill group. Six of the nine COVID-19 critically ill patients had random plasma cortisol concentrations below 10 microg/dl, which met the criteria for the diagnosis of CIRCI. CONCLUSION: We demonstrate that ACE2 and TMPRSS2 are colocalized in adrenocortical cells, and that the cortisol levels are lower in critically ill patients with COVID-19 as compared to those of non-COVID-19 critically ill patients. Based on our findings, we recommend measuring plasma cortisol level to guide hormonal therapy. |Adrenal Cortex Diseases/*drug therapy/*virology[MESH] |Adrenal Cortex/enzymology/*virology[MESH] |Adrenal Insufficiency/etiology/therapy[MESH] |Adult[MESH] |Aged[MESH] |Aged, 80 and over[MESH] |Angiotensin-Converting Enzyme 2/metabolism[MESH] |COVID-19 Drug Treatment[MESH] |COVID-19/*virology[MESH] |Critical Illness[MESH] |Dexamethasone/therapeutic use[MESH] |Female[MESH] |Humans[MESH] |Hydrocortisone/blood[MESH] |Male[MESH] |Middle Aged[MESH] |Serine Endopeptidases/metabolism[MESH] |Vasoconstrictor Agents/therapeutic use[MESH] |Zona Fasciculata/metabolism[MESH]The Adrenal Cortex, an Underestimated Site of SARS-CoV-2 Infection (epmc).pdf DeepDyve Pubget Overpricing