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10.1080/21541248.2021.1877081 http://scihub22266oqcxt.onion/10.1080/21541248.2021.1877081 33487105!8583085!33487105     free     free     free       Small+GTPases 2021 ; 12 (5-6): 429-439 Nephropedia Template TP {{tp|p=33487105|t=2021. Small GTPases all over invadosomes |pdf=|usr=}}{{33487105}} gab.com Text Small GTPases all over invadosomes JO: Small GTPases http://www.kidney.de/pget.php?&tw=1&pmid=33487105 #FOAvip Cell invasion is associated with numerous patho-physiologic states including cell development and metastatic dissemination. This process couples the activation of cell motility with the capacity to degrade the extracellular matrix, thereby permitting cells to pass through basal membranes. Invasion is sustained by the actions of invadosomes, an ensemble of subcellular structures with high functional homology. Invadosomes are 3D acto-adhesive structures that can also mediate local extracellular matrix degradation through the controlled delivery of proteases. Intracellular RHO GTPases play a central role in the regulation of invadosomes where their complex interplay regulates multiple invadosome functions. This review aims to provide an overview of the synergistic activities of the small GTPases in invadosome biology. This broad-based review also reinforces the importance of the spatiotemporal regulation of small GTPases and the impact of this process on invadosome dynamics. Twit Text FOAVip Small GTPases all over invadosomes ????Small GTPases http://www.kidney.de/pget.php?&tw=1&pmid=33487105 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33487105 #FOAvip English Wikipedia <ref>{{Cite pmid|33487105}}</ref> Small GTPases all over invadosomes #MMPMID33487105 Rivier P; Mubalama M; Destaing O Small GTPases 2021[Sep]; 12 (5-6): 429-439 PMID33487105show ga Cell invasion is associated with numerous patho-physiologic states including cell development and metastatic dissemination. This process couples the activation of cell motility with the capacity to degrade the extracellular matrix, thereby permitting cells to pass through basal membranes. Invasion is sustained by the actions of invadosomes, an ensemble of subcellular structures with high functional homology. Invadosomes are 3D acto-adhesive structures that can also mediate local extracellular matrix degradation through the controlled delivery of proteases. Intracellular RHO GTPases play a central role in the regulation of invadosomes where their complex interplay regulates multiple invadosome functions. This review aims to provide an overview of the synergistic activities of the small GTPases in invadosome biology. This broad-based review also reinforces the importance of the spatiotemporal regulation of small GTPases and the impact of this process on invadosome dynamics. |*Cell Movement[MESH] |Actin Cytoskeleton/enzymology/*physiology[MESH] |Animals[MESH] |Extracellular Matrix/*metabolism[MESH] |Humans[MESH] |Monomeric GTP-Binding Proteins/*metabolism[MESH]Small GTPases all over invadosomes (epmc).pdf DeepDyve Pubget Overpricing