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10.1093/qjmed/hcab009 http://scihub22266oqcxt.onion/10.1093/qjmed/hcab009 33486522!7928587!33486522     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       QJM 2021 ; 114 (3): 175-181 Nephropedia Template TP {{tp|p=33486522|t=2021. Vitamin D supplementation, COVID-19 and disease severity: a meta-analysis |pdf=|usr=}}{{33486522}} gab.com Text Vitamin D supplementation, COVID-19 and disease severity: a meta-analysis JO: QJM http://www.kidney.de/pget.php?&tw=1&pmid=33486522 #FOAvip OBJECTIVE: Current meta-analysis aims to understand the effect of oral supplementation of vitamin D on intensive care unit (ICU) requirement and mortality in hospitalized COVID-19 patients. METHODS: Databases PubMed, preprint servers, and google scholar were searched from December 2019 to December 2020. Authors searched for the articles assessing role of vitamin D supplementation on COVID-19. Cochrane RevMan tool was used for quantitative assessment of the data, where heterogeneity was assessed using I2 and Q statistics and data was expressed using odds ratio with 95% confidence interval. RESULTS: Final meta-analysis involved pooled data of 532 hospitalized patients (189 on vitamin D supplementation and 343 on usual care/placebo) of COVID-19 from three studies (Two randomized controlled trials, one retrospective case-control study). Statistically (p<0.0001) lower ICU requirement was observed in patients with vitamin D supplementation as compared to patients without supplementations (odds ratio: 0.36; 95% CI: 0.210-0.626). However, it suffered from significant heterogeneity, which reduced after sensitivity analysis. In case of mortality, vitamin D supplements has comparable findings with placebo treatment/usual care (odds ratio: 0.93; 95% CI: 0.413-2.113; p=0.87). The studies did not show any publication bias and had fair quality score. Subgroup analysis could not be performed due to limited number of studies and hence dose and duration dependent effect of vitamin D could not be evaluated. CONCLUSIONS: Although the current meta-analysis findings indicate potential role of vitamin D in improving COVID-19 severity in hospitalized patients, more robust data from randomized controlled trials are needed to substantiate its effects on mortality. Twit Text FOAVip Vitamin D supplementation, COVID-19 and disease severity: a meta-analysis ????QJM http://www.kidney.de/pget.php?&tw=1&pmid=33486522 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33486522 #FOAvip English Wikipedia <ref>{{Cite pmid|33486522}}</ref> Vitamin D supplementation, COVID-19 and disease severity: a meta-analysis #MMPMID33486522 Shah K; Saxena D; Mavalankar D QJM 2021[May]; 114 (3): 175-181 PMID33486522show ga OBJECTIVE: Current meta-analysis aims to understand the effect of oral supplementation of vitamin D on intensive care unit (ICU) requirement and mortality in hospitalized COVID-19 patients. METHODS: Databases PubMed, preprint servers, and google scholar were searched from December 2019 to December 2020. Authors searched for the articles assessing role of vitamin D supplementation on COVID-19. Cochrane RevMan tool was used for quantitative assessment of the data, where heterogeneity was assessed using I2 and Q statistics and data was expressed using odds ratio with 95% confidence interval. RESULTS: Final meta-analysis involved pooled data of 532 hospitalized patients (189 on vitamin D supplementation and 343 on usual care/placebo) of COVID-19 from three studies (Two randomized controlled trials, one retrospective case-control study). Statistically (p<0.0001) lower ICU requirement was observed in patients with vitamin D supplementation as compared to patients without supplementations (odds ratio: 0.36; 95% CI: 0.210-0.626). However, it suffered from significant heterogeneity, which reduced after sensitivity analysis. In case of mortality, vitamin D supplements has comparable findings with placebo treatment/usual care (odds ratio: 0.93; 95% CI: 0.413-2.113; p=0.87). The studies did not show any publication bias and had fair quality score. Subgroup analysis could not be performed due to limited number of studies and hence dose and duration dependent effect of vitamin D could not be evaluated. CONCLUSIONS: Although the current meta-analysis findings indicate potential role of vitamin D in improving COVID-19 severity in hospitalized patients, more robust data from randomized controlled trials are needed to substantiate its effects on mortality. |*COVID-19 Drug Treatment[MESH] |*Critical Care[MESH] |Administration, Oral[MESH] |COVID-19/*mortality[MESH] |Hospitalization[MESH] |Humans[MESH] |Pneumonia, Viral/*drug therapy/*mortality/virology[MESH] |SARS-CoV-2[MESH] |Severity of Illness Index[MESH]Vitamin D supplementation, COVID-19 and disease severity: a meta-analy(epmc).pdf DeepDyve Pubget Overpricing