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10.1016/j.biopha.2021.111232 http://scihub22266oqcxt.onion/10.1016/j.biopha.2021.111232 33486202!7834004!33486202     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biomed+Pharmacother 2021 ; 137 (ä): 111232 Nephropedia Template TP {{tp|p=33486202|t=2021. Human endeavor for anti-SARS-CoV-2 pharmacotherapy: A major strategy to fight the pandemic |pdf=|usr=}}{{33486202}} gab.com Text Human endeavor for anti-SARS-CoV-2 pharmacotherapy: A major strategy to fight the pandemic JO: Biomed Pharmacother http://www.kidney.de/pget.php?&tw=1&pmid=33486202 #FOAvip The global spread of COVID-19 constitutes the most dangerous pandemic to emerge during the last one hundred years. About seventy-nine million infections and more than 1.7 million death have been reported to date, along with destruction of the global economy. With the uncertainty evolved by alarming level of genome mutations, coupled with likelihood of generating only a short lived immune response by the vaccine injections, the identification of antiviral drugs for direct therapy is the need of the hour. Strategies to inhibit virus infection and replication focus on targets such as the spike protein and non-structural proteins including the highly conserved RNA-dependent-RNA-polymerase, nucleotidyl-transferases, main protease and papain-like proteases. There is also an indirect option to target the host cell recognition systems such as angiotensin-converting enzyme 2 (ACE2), transmembrane protease, serine 2, host cell expressed CD147, and the host furin. A drug search strategy consensus in tandem with analysis of currently available information is extremely important for the rapid identification of anti-viral. An unprecedented display of cooperation among the scientific community regarding SARS-CoV-2 research has resulted in the accumulation of an enormous amount of literature that requires curation. Drug repurposing and drug combinations have drawn tremendous attention for rapid therapeutic application, while high throughput screening and virtual searches support de novo drug identification. Here, we examine how certain approved drugs targeting different viruses can play a role in combating this new virus and analyze how they demonstrate efficacy under clinical assessment. Suggestions on repurposing and de novo strategies are proposed to facilitate the fight against the COVID-19 pandemic. Twit Text FOAVip Human endeavor for anti-SARS-CoV-2 pharmacotherapy: A major strategy to fight the pandemic ????Biomed Pharmacother http://www.kidney.de/pget.php?&tw=1&pmid=33486202 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33486202 #FOAvip English Wikipedia <ref>{{Cite pmid|33486202}}</ref> Human endeavor for anti-SARS-CoV-2 pharmacotherapy: A major strategy to fight the pandemic #MMPMID33486202 Wang R; Stephen P; Tao Y; Zhang W; Lin SX Biomed Pharmacother 2021[May]; 137 (ä): 111232 PMID33486202show ga The global spread of COVID-19 constitutes the most dangerous pandemic to emerge during the last one hundred years. About seventy-nine million infections and more than 1.7 million death have been reported to date, along with destruction of the global economy. With the uncertainty evolved by alarming level of genome mutations, coupled with likelihood of generating only a short lived immune response by the vaccine injections, the identification of antiviral drugs for direct therapy is the need of the hour. Strategies to inhibit virus infection and replication focus on targets such as the spike protein and non-structural proteins including the highly conserved RNA-dependent-RNA-polymerase, nucleotidyl-transferases, main protease and papain-like proteases. There is also an indirect option to target the host cell recognition systems such as angiotensin-converting enzyme 2 (ACE2), transmembrane protease, serine 2, host cell expressed CD147, and the host furin. A drug search strategy consensus in tandem with analysis of currently available information is extremely important for the rapid identification of anti-viral. An unprecedented display of cooperation among the scientific community regarding SARS-CoV-2 research has resulted in the accumulation of an enormous amount of literature that requires curation. Drug repurposing and drug combinations have drawn tremendous attention for rapid therapeutic application, while high throughput screening and virtual searches support de novo drug identification. Here, we examine how certain approved drugs targeting different viruses can play a role in combating this new virus and analyze how they demonstrate efficacy under clinical assessment. Suggestions on repurposing and de novo strategies are proposed to facilitate the fight against the COVID-19 pandemic. |*COVID-19 Drug Treatment[MESH] |*COVID-19/epidemiology[MESH] |*SARS-CoV-2/drug effects/physiology[MESH] |Antiviral Agents/*pharmacology[MESH] |Drug Development/methods[MESH] |Drug Repositioning/methods[MESH] |Humans[MESH] |Treatment Outcome[MESH] |Viral Proteins/antagonists & inhibitors/genetics[MESH]Human endeavor for anti-SARS-CoV-2 pharmacotherapy: A major strategy t(epmc).pdf DeepDyve Pubget Overpricing