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10.1016/j.drudis.2021.01.010 http://scihub22266oqcxt.onion/10.1016/j.drudis.2021.01.010 33486116!7825840!33486116     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Drug+Discov+Today 2021 ; 26 (4): 870-874 Nephropedia Template TP {{tp|p=33486116|t=2021. Drugs acting on the renin-angiotensin system and SARS-CoV-2 |pdf=|usr=}}{{33486116}} gab.com Text Drugs acting on the renin-angiotensin system and SARS-CoV-2 JO: Drug Discov Today http://www.kidney.de/pget.php?&tw=1&pmid=33486116 #FOAvip Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the ongoing global Coronavirus 2019 (COVID-19) pandemic, resulting in thousands of deaths worldwide and representing a health challenge with few precedents in human history. Angiotensin-converting enzyme 2 (ACE-2) facilitates the access of SARS-CoV-2 to cells. Therapeutic agents acting on the renin-angiotensin system (RAS) might be able to modulate the concentration of ACE-2 and the various components of the system. Here, we discuss current pharmacological, molecular, and clinical evidence to investigate whether drugs acting on RAS with modulation of the ACE-2 concentration have added value in combating SARS-CoV-2 infection. We also highlight the possible deleterious action of the ACE/Ang-II/AT-1r axis and possible beneficial role of the ACE-2/Ang 1-7/MasR axis in acute respiratory distress syndrome (ARDS) caused by SARS-CoV-2, discussing the possibility of addressing the various RAS components with drug treatments to improve clinical outcomes. Twit Text FOAVip Drugs acting on the renin-angiotensin system and SARS-CoV-2 ????Drug Discov Today http://www.kidney.de/pget.php?&tw=1&pmid=33486116 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33486116 #FOAvip English Wikipedia <ref>{{Cite pmid|33486116}}</ref> Drugs acting on the renin-angiotensin system and SARS-CoV-2 #MMPMID33486116 Vitiello A; Pelliccia C; Ferrara F Drug Discov Today 2021[Apr]; 26 (4): 870-874 PMID33486116show ga Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the ongoing global Coronavirus 2019 (COVID-19) pandemic, resulting in thousands of deaths worldwide and representing a health challenge with few precedents in human history. Angiotensin-converting enzyme 2 (ACE-2) facilitates the access of SARS-CoV-2 to cells. Therapeutic agents acting on the renin-angiotensin system (RAS) might be able to modulate the concentration of ACE-2 and the various components of the system. Here, we discuss current pharmacological, molecular, and clinical evidence to investigate whether drugs acting on RAS with modulation of the ACE-2 concentration have added value in combating SARS-CoV-2 infection. We also highlight the possible deleterious action of the ACE/Ang-II/AT-1r axis and possible beneficial role of the ACE-2/Ang 1-7/MasR axis in acute respiratory distress syndrome (ARDS) caused by SARS-CoV-2, discussing the possibility of addressing the various RAS components with drug treatments to improve clinical outcomes. |*COVID-19 Drug Treatment[MESH] |*SARS-CoV-2/drug effects/physiology[MESH] |Angiotensin-Converting Enzyme 2/metabolism[MESH] |COVID-19/metabolism/prevention & control[MESH] |Humans[MESH] |Renin-Angiotensin System/*drug effects[MESH]Drugs acting on the renin-angiotensin system and SARS-CoV-2 (epmc).pdf DeepDyve Pubget Overpricing