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10.1016/j.celrep.2021.108699

http://scihub22266oqcxt.onion/10.1016/j.celrep.2021.108699
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suck abstract from ncbi


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pmid33485405      Cell+Rep 2021 ; 34 (5): 108699
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  • Enhancement versus neutralization by SARS-CoV-2 antibodies from a convalescent donor associates with distinct epitopes on the RBD #MMPMID33485405
  • Zhou Y; Liu Z; Li S; Xu W; Zhang Q; Silva IT; Li C; Wu Y; Jiang Q; Liu Z; Wang Q; Guo Y; Wu J; Gu C; Cai X; Qu D; Mayer CT; Wang X; Jiang S; Ying T; Yuan Z; Xie Y; Wen Y; Lu L; Wang Q
  • Cell Rep 2021[Feb]; 34 (5): 108699 PMID33485405show ga
  • Several potent neutralizing antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus have been identified. However, antibody-dependent enhancement (ADE) has not been comprehensively studied for SARS-CoV-2, and the relationship between enhancing versus neutralizing activities and antibody epitopes remains unknown. Here, we select a convalescent individual with potent IgG neutralizing activity and characterize his antibody response. Monoclonal antibodies isolated from memory B cells target four groups of five non-overlapping receptor-binding domain (RBD) epitopes. Antibodies to one group of these RBD epitopes mediate ADE of entry in Raji cells via an Fcgamma receptor-dependent mechanism. In contrast, antibodies targeting two other distinct epitope groups neutralize SARS-CoV-2 without ADE, while antibodies against the fourth epitope group are poorly neutralizing. One antibody, XG014, potently cross-neutralizes SARS-CoV-2 variants, as well as SARS-CoV-1, with respective IC(50) (50% inhibitory concentration) values as low as 5.1 and 23.7 ng/mL, while not exhibiting ADE. Therefore, neutralization and ADE of human SARS-CoV-2 antibodies correlate with non-overlapping RBD epitopes.
  • |*Antibody-Dependent Enhancement[MESH]
  • |Adolescent[MESH]
  • |Adult[MESH]
  • |Aged[MESH]
  • |Antibodies, Monoclonal/immunology[MESH]
  • |Antibodies, Neutralizing/*immunology[MESH]
  • |Antibodies, Viral/*immunology/therapeutic use[MESH]
  • |Antigen-Antibody Reactions[MESH]
  • |COVID-19 Drug Treatment[MESH]
  • |COVID-19/immunology/virology[MESH]
  • |Cell Line[MESH]
  • |Child[MESH]
  • |Cluster Analysis[MESH]
  • |Epitopes/*immunology[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Inhibitory Concentration 50[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Protein Domains/immunology[MESH]
  • |SARS-CoV-2/isolation & purification[MESH]
  • |Spike Glycoprotein, Coronavirus/chemistry/immunology[MESH]


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