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Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Biomol+NMR+Assign 2021 ; 15 (1): 203-211 Nephropedia Template TP
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(1)H, (13)C and (15)N chemical shift assignment of the stem-loop 5a from the 5 -UTR of SARS-CoV-2 #MMPMID33484403
Biomol NMR Assign 2021[Apr]; 15 (1): 203-211 PMID33484403show ga
The SARS-CoV-2 (SCoV-2) virus is the causative agent of the ongoing COVID-19 pandemic. It contains a positive sense single-stranded RNA genome and belongs to the genus of Betacoronaviruses. The 5'- and 3'-genomic ends of the 30 kb SCoV-2 genome are potential antiviral drug targets. Major parts of these sequences are highly conserved among Betacoronaviruses and contain cis-acting RNA elements that affect RNA translation and replication. The 31 nucleotide (nt) long highly conserved stem-loop 5a (SL5a) is located within the 5'-untranslated region (5'-UTR) important for viral replication. SL5a features a U-rich asymmetric bulge and is capped with a 5'-UUUCGU-3' hexaloop, which is also found in stem-loop 5b (SL5b). We herein report the extensive (1)H, (13)C and (15)N resonance assignment of SL5a as basis for in-depth structural studies by solution NMR spectroscopy.