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10.1111/crj.13331

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33484220!8014806!33484220
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suck abstract from ncbi


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pmid33484220      Clin+Respir+J 2021 ; 15 (5): 499-505
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  • Development of a SARS-CoV-2 rapid antibody detection kit and study on dynamic changes in antibodies in infected patients #MMPMID33484220
  • Wang H; Li X; Li T; Wang L; Wang L; Lin J; Zhang S; Xu Y; Wei W
  • Clin Respir J 2021[May]; 15 (5): 499-505 PMID33484220show ga
  • INTRODUCTION: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread rapidly to 185 regions and countries around the world with more than 2.8 million confirmed infections and 203,044 deaths. Respiratory diseases caused by SARS-CoV-2 are serious threats to human health. OBJECTIVES: To develop a rapid detection kit for new coronavirus antibodies and use it to study the dynamic changes in antibodies in clinically confirmed SARS-CoV-2-infected patients. METHODS: The SARS-CoV-2 IgM/IgG antibody test kit (colloidal gold method) was developed. Serum SARS-CoV-2 IgM and IgG antibodies were tested in SARS-CoV-2- and non-SARS-CoV-2-infected persons, respectively. RESULTS AND CONCLUSION: The sensitivities of the SARS-CoV-2 IgM/IgG antibody test kit (colloidal gold method) were 50%, 70%, 92.5% and 97.5% after 1-3 days, 4-6 days, 7-9 days and >9 days of admission, respectively, and the specificities of the IgM, IgG and IgM + IgG antibodies were all 100%. Using the SARS-CoV-2 IgM/IgG antibody test kit (colloidal gold method), the positive rates of SARS-CoV-2 IgM and IgG antibodies increased from 50% to 92.5% after 1-3 days, 4-6 days and 7-9 days of admission, which showed an increasing trend. The titers of the SARS-CoV-2 IgM and IgG antibodies in the positive specimens increased with the length of admission.
  • |Adult[MESH]
  • |Antibodies, Viral/*blood[MESH]
  • |COVID-19/*diagnosis/epidemiology[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Immunoglobulin G/*blood[MESH]
  • |Immunoglobulin M/blood/*immunology[MESH]
  • |Male[MESH]
  • |Pandemics[MESH]


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