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10.1038/s41467-020-20642-x http://scihub22266oqcxt.onion/10.1038/s41467-020-20642-x 33483492!7822826!33483492     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2021 ; 12 (1): 541 Nephropedia Template TP {{tp|p=33483492|t=2021. SARS-CoV-2 induces robust germinal center CD4 T follicular helper cell responses in rhesus macaques |pdf=|usr=}}{{33483492}} gab.com Text SARS-CoV-2 induces robust germinal center CD4 T follicular helper cell responses in rhesus macaques JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=33483492 #FOAvip CD4 T follicular helper (T(fh)) cells are important for the generation of durable and specific humoral protection against viral infections. The degree to which SARS-CoV-2 infection generates T(fh) cells and stimulates the germinal center (GC) response is an important question as we investigate vaccine induced immunity against COVID-19. Here, we report that SARS-CoV-2 infection in rhesus macaques, either infused with convalescent plasma, normal plasma, or receiving no infusion, resulted in transient accumulation of pro-inflammatory monocytes and proliferating T(fh) cells with a T(h)1 profile in peripheral blood. CD4 helper cell responses skewed predominantly toward a T(h)1 response in blood, lung, and lymph nodes. SARS-CoV-2 Infection induced GC T(fh) cells specific for the SARS-CoV-2 spike and nucleocapsid proteins, and a corresponding early appearance of antiviral serum IgG antibodies. Collectively, the data show induction of GC responses in a rhesus model of mild COVID-19. Twit Text FOAVip SARS-CoV-2 induces robust germinal center CD4 T follicular helper cell responses in rhesus macaques ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=33483492 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33483492 #FOAvip English Wikipedia <ref>{{Cite pmid|33483492}}</ref> SARS-CoV-2 induces robust germinal center CD4 T follicular helper cell responses in rhesus macaques #MMPMID33483492 Shaan Lakshmanappa Y; Elizaldi SR; Roh JW; Schmidt BA; Carroll TD; Weaver KD; Smith JC; Verma A; Deere JD; Dutra J; Stone M; Franz S; Sammak RL; Olstad KJ; Rachel Reader J; Ma ZM; Nguyen NK; Watanabe J; Usachenko J; Immareddy R; Yee JL; Weiskopf D; Sette A; Hartigan-O'Connor D; McSorley SJ; Morrison JH; Tran NK; Simmons G; Busch MP; Kozlowski PA; Van Rompay KKA; Miller CJ; Iyer SS Nat Commun 2021[Jan]; 12 (1): 541 PMID33483492show ga CD4 T follicular helper (T(fh)) cells are important for the generation of durable and specific humoral protection against viral infections. The degree to which SARS-CoV-2 infection generates T(fh) cells and stimulates the germinal center (GC) response is an important question as we investigate vaccine induced immunity against COVID-19. Here, we report that SARS-CoV-2 infection in rhesus macaques, either infused with convalescent plasma, normal plasma, or receiving no infusion, resulted in transient accumulation of pro-inflammatory monocytes and proliferating T(fh) cells with a T(h)1 profile in peripheral blood. CD4 helper cell responses skewed predominantly toward a T(h)1 response in blood, lung, and lymph nodes. SARS-CoV-2 Infection induced GC T(fh) cells specific for the SARS-CoV-2 spike and nucleocapsid proteins, and a corresponding early appearance of antiviral serum IgG antibodies. Collectively, the data show induction of GC responses in a rhesus model of mild COVID-19. |Animals[MESH] |Antibodies, Viral/blood[MESH] |COVID-19 Serotherapy[MESH] |COVID-19/*immunology/therapy[MESH] |Cell Line[MESH] |Chlorocebus aethiops[MESH] |Coronavirus Nucleocapsid Proteins/immunology[MESH] |Disease Models, Animal[MESH] |Female[MESH] |Germinal Center/*immunology[MESH] |Humans[MESH] |Immunity, Humoral/immunology[MESH] |Immunization, Passive[MESH] |Immunogenicity, Vaccine/immunology[MESH] |Immunoglobulin G/blood[MESH] |Macaca mulatta[MESH] |Male[MESH] |Phosphoproteins/immunology[MESH] |SARS-CoV-2/*immunology/isolation & purification[MESH] |Spike Glycoprotein, Coronavirus/immunology[MESH] |T Follicular Helper Cells/*immunology[MESH] |Th1 Cells/*immunology[MESH]SARS-CoV-2 induces robust germinal center CD4 T follicular helper cell(epmc).pdf DeepDyve Pubget Overpricing