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Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Adv+Drug+Deliv+Rev 2021 ; 172 (ä): 314-338 Nephropedia Template TP
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SARS-CoV-2 vaccines in advanced clinical trials: Where do we stand? #MMPMID33482248
Chakraborty S; Mallajosyula V; Tato CM; Tan GS; Wang TT
Adv Drug Deliv Rev 2021[May]; 172 (ä): 314-338 PMID33482248show ga
The ongoing SARS-CoV-2 pandemic has led to the focused application of resources and scientific expertise toward the goal of developing investigational vaccines to prevent COVID-19. The highly collaborative global efforts by private industry, governments and non-governmental organizations have resulted in a number of SARS-CoV-2 vaccine candidates moving to Phase III trials in a period of only months since the start of the pandemic. In this review, we provide an overview of the preclinical and clinical data on SARS-CoV-2 vaccines that are currently in Phase III clinical trials and in few cases authorized for emergency use. We further discuss relevant vaccine platforms and provide a discussion of SARS-CoV-2 antigens that may be targeted to increase the breadth and durability of vaccine responses.