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10.1111/bjh.17272

http://scihub22266oqcxt.onion/10.1111/bjh.17272
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33482025!8014171!33482025
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suck abstract from ncbi


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pmid33482025      Br+J+Haematol 2021 ; 192 (4): 706-713
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  • Early mortality benefit with COVID-19 convalescent plasma: a matched control study #MMPMID33482025
  • Shenoy AG; Hettinger AZ; Fernandez SJ; Blumenthal J; Baez V
  • Br J Haematol 2021[Feb]; 192 (4): 706-713 PMID33482025show ga
  • Convalescent plasma can provide passive immunity during viral outbreaks, but the benefit is uncertain for the treatment of novel coronavirus disease 2019 (COVID-19). Our goal is to assess the efficacy of COVID-19 convalescent plasma (CCP). In all, 526 hospitalized patients with laboratory-confirmed SARS-CoV-2 at an academic health system were analyzed. Among them, 263 patients received CCP and were compared to 263 matched controls with standard treatment. The primary outcome was 28-day mortality with a subanalysis at 7 and 14 days. No statistical difference in 28-day mortality was seen in CCP cases (25.5%) compared to controls (27%, P = 0.06). Seven-day mortality was statistically better for CCP cases (9.1%) than controls (19.8%, P < 0.001) and continued at 14 days (14.8% vs. 23.6%, P = 0.01). After 72 h, CCP transfusion resulted in transitioning from nasal cannula to room air (median 4 days vs. 1 day, P = 0.02). The length of stay was longer in CCP cases than controls (14.3 days vs. 11.4 days, P < 0.001). Patients with COVID-19 who received CCP had a decreased risk of death at 7 and 14 days, but not 28 days after transfusion. To date, this is the largest study demonstrating a mortality benefit for the use of CCP in patients with COVID-19 compared to matched controls.
  • |Adult[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |COVID-19 Serotherapy[MESH]
  • |COVID-19/blood/mortality/*therapy[MESH]
  • |Disease-Free Survival[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Immunization, Passive[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Retrospective Studies[MESH]
  • |Risk Factors[MESH]
  • |SARS-CoV-2/*metabolism[MESH]
  • |Survival Rate[MESH]


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