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10.1097/RLI.0000000000000763

http://scihub22266oqcxt.onion/10.1097/RLI.0000000000000763
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33481459!ä!33481459

suck abstract from ncbi


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pmid33481459      Invest+Radiol 2021 ; 56 (8): 471-479
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  • Automated Detection and Quantification of COVID-19 Airspace Disease on Chest Radiographs: A Novel Approach Achieving Expert Radiologist-Level Performance Using a Deep Convolutional Neural Network Trained on Digital Reconstructed Radiographs From Computed Tomography-Derived Ground Truth #MMPMID33481459
  • Mortani Barbosa EJ Jr; Gefter WB; Ghesu FC; Liu S; Mailhe B; Mansoor A; Grbic S; Vogt S
  • Invest Radiol 2021[Aug]; 56 (8): 471-479 PMID33481459show ga
  • OBJECTIVES: The aim of this study was to leverage volumetric quantification of airspace disease (AD) derived from a superior modality (computed tomography [CT]) serving as ground truth, projected onto digitally reconstructed radiographs (DRRs) to (1) train a convolutional neural network (CNN) to quantify AD on paired chest radiographs (CXRs) and CTs, and (2) compare the DRR-trained CNN to expert human readers in the CXR evaluation of patients with confirmed COVID-19. MATERIALS AND METHODS: We retrospectively selected a cohort of 86 COVID-19 patients (with positive reverse transcriptase-polymerase chain reaction test results) from March to May 2020 at a tertiary hospital in the northeastern United States, who underwent chest CT and CXR within 48 hours. The ground-truth volumetric percentage of COVID-19-related AD (POv) was established by manual AD segmentation on CT. The resulting 3-dimensional masks were projected into 2-dimensional anterior-posterior DRR to compute area-based AD percentage (POa). A CNN was trained with DRR images generated from a larger-scale CT dataset of COVID-19 and non-COVID-19 patients, automatically segmenting lungs, AD, and quantifying POa on CXR. The CNN POa results were compared with POa quantified on CXR by 2 expert readers and to the POv ground truth, by computing correlations and mean absolute errors. RESULTS: Bootstrap mean absolute error and correlations between POa and POv were 11.98% (11.05%-12.47%) and 0.77 (0.70-0.82) for average of expert readers and 9.56% to 9.78% (8.83%-10.22%) and 0.78 to 0.81 (0.73-0.85) for the CNN, respectively. CONCLUSIONS: Our CNN trained with DRR using CT-derived airspace quantification achieved expert radiologist level of accuracy in the quantification of AD on CXR in patients with positive reverse transcriptase-polymerase chain reaction test results for COVID-19.
  • |*Deep Learning[MESH]
  • |*Radiography, Thoracic[MESH]
  • |*Radiologists[MESH]
  • |*Tomography, X-Ray Computed[MESH]
  • |COVID-19/*diagnostic imaging[MESH]
  • |Cohort Studies[MESH]
  • |Humans[MESH]
  • |Image Processing, Computer-Assisted/*methods[MESH]
  • |Lung/diagnostic imaging[MESH]
  • |Male[MESH]


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