Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1007/s00109-021-02037-7 http://scihub22266oqcxt.onion/10.1007/s00109-021-02037-7 33481059!7900031!33481059     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Mol+Med+(Berl) 2021 ; 99 (3): 335-348 Nephropedia Template TP {{tp|p=33481059|t=2021. Vascular pathologies in chronic kidney disease: pathophysiological mechanisms and novel therapeutic approaches |pdf=|usr=}}{{33481059}} gab.com Text Vascular pathologies in chronic kidney disease: pathophysiological mechanisms and novel therapeutic approaches JO: J Mol Med (Berl) http://www.kidney.de/pget.php?&tw=1&pmid=33481059 #FOAvip Cardiovascular disease (CVD) is a major cause of death in patients with chronic kidney disease (CKD). Both conditions are rising in incidence as well as prevalence, creating poor outcomes for patients and high healthcare costs. Recent data suggests CKD to be an independent risk factor for CVD. Accumulation of uremic toxins, chronic inflammation, and oxidative stress have been identified to act as CKD-specific alterations that increase cardiovascular risk. The association between CKD and cardiovascular mortality is markedly influenced through vascular alterations, in particular atherosclerosis and vascular calcification (VC). While numerous risk factors promote atherosclerosis by inducing endothelial dysfunction and its progress to vascular structural damage, CKD affects the medial layer of blood vessels primarily through VC. Ongoing research has identified VC to be a multifactorial, cell-mediated process in which numerous abnormalities like mineral dysregulation and especially hyperphosphatemia induce a phenotype switch of vascular smooth muscle cells to osteoblast-like cells. A combination of pro-calcifying stimuli and an impairment of inhibiting mechanisms like fetuin A and vitamin K-dependent proteins like matrix Gla protein and Gla-rich protein leads to mineralization of the extracellular matrix. In view of recent studies, intercellular communication pathways via extracellular vesicles and microRNAs represent key mechanisms in VC and thereby a promising field to a deeper understanding of the involved pathomechanisms. In this review, we provide an overview about pathophysiological mechanisms connecting CKD and CVD. Special emphasis is laid on vascular alterations and more recently discovered molecular pathways which present possible new therapeutic targets. Twit Text FOAVip Vascular pathologies in chronic kidney disease: pathophysiological mechanisms and novel therapeutic approaches ????J Mol Med (Berl) http://www.kidney.de/pget.php?&tw=1&pmid=33481059 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33481059 #FOAvip English Wikipedia <ref>{{Cite pmid|33481059}}</ref> Vascular pathologies in chronic kidney disease: pathophysiological mechanisms and novel therapeutic approaches #MMPMID33481059 Dusing P; Zietzer A; Goody PR; Hosen MR; Kurts C; Nickenig G; Jansen F J Mol Med (Berl) 2021[Mar]; 99 (3): 335-348 PMID33481059show ga Cardiovascular disease (CVD) is a major cause of death in patients with chronic kidney disease (CKD). Both conditions are rising in incidence as well as prevalence, creating poor outcomes for patients and high healthcare costs. Recent data suggests CKD to be an independent risk factor for CVD. Accumulation of uremic toxins, chronic inflammation, and oxidative stress have been identified to act as CKD-specific alterations that increase cardiovascular risk. The association between CKD and cardiovascular mortality is markedly influenced through vascular alterations, in particular atherosclerosis and vascular calcification (VC). While numerous risk factors promote atherosclerosis by inducing endothelial dysfunction and its progress to vascular structural damage, CKD affects the medial layer of blood vessels primarily through VC. Ongoing research has identified VC to be a multifactorial, cell-mediated process in which numerous abnormalities like mineral dysregulation and especially hyperphosphatemia induce a phenotype switch of vascular smooth muscle cells to osteoblast-like cells. A combination of pro-calcifying stimuli and an impairment of inhibiting mechanisms like fetuin A and vitamin K-dependent proteins like matrix Gla protein and Gla-rich protein leads to mineralization of the extracellular matrix. In view of recent studies, intercellular communication pathways via extracellular vesicles and microRNAs represent key mechanisms in VC and thereby a promising field to a deeper understanding of the involved pathomechanisms. In this review, we provide an overview about pathophysiological mechanisms connecting CKD and CVD. Special emphasis is laid on vascular alterations and more recently discovered molecular pathways which present possible new therapeutic targets. |Animals[MESH] |Atherosclerosis/*etiology[MESH] |Cardio-Renal Syndrome/classification/epidemiology/*etiology/physiopathology[MESH] |Disease Models, Animal[MESH] |Endothelium, Vascular/physiopathology[MESH] |Extracellular Vesicles/physiology[MESH] |Heart Disease Risk Factors[MESH] |Humans[MESH] |Incidence[MESH] |Inflammation[MESH] |Mice[MESH] |MicroRNAs/genetics/therapeutic use[MESH] |Myocytes, Smooth Muscle/pathology[MESH] |Rats[MESH] |Renal Insufficiency, Chronic/complications/*physiopathology[MESH] |Tunica Media/pathology[MESH] |Vascular Calcification/drug therapy/*etiology/prevention & control[MESH] |Vitamin K 1/therapeutic use[MESH]Vascular pathologies in chronic kidney disease: pathophysiological mec(epmc).pdf DeepDyve Pubget Overpricing