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10.1021/acsnano.0c10180

http://scihub22266oqcxt.onion/10.1021/acsnano.0c10180
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33480671!ä!33480671

suck abstract from ncbi


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pmid33480671      ACS+Nano 2021 ; 15 (6): 9627-9637
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  • Design of SARS-CoV-2 hFc-Conjugated Receptor-Binding Domain mRNA Vaccine Delivered via Lipid Nanoparticles #MMPMID33480671
  • Elia U; Ramishetti S; Rosenfeld R; Dammes N; Bar-Haim E; Naidu GS; Makdasi E; Yahalom-Ronen Y; Tamir H; Paran N; Cohen O; Peer D
  • ACS Nano 2021[Jun]; 15 (6): 9627-9637 PMID33480671show ga
  • Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been identified as the causal agent of COVID-19 and stands at the center of the current global human pandemic, with death toll exceeding one million. The urgent need for a vaccine has led to the development of various immunization approaches. mRNA vaccines represent a cell-free, simple, and rapid platform for immunization, and therefore have been employed in recent studies toward the development of a SARS-CoV-2 vaccine. Herein, we present the design of an mRNA vaccine, based on lipid nanoparticles (LNPs)-encapsulated SARS-CoV-2 human Fc-conjugated receptor-binding domain (RBD-hFc). Several ionizable lipids have been evaluated in vivo in a luciferase (luc) mRNA reporter assay, and two leading LNPs formulations have been chosen for the subsequent RBD-hFc mRNA vaccine strategy. Intramuscular administration of LNP RBD-hFc mRNA elicited robust humoral response, a high level of neutralizing antibodies and a Th1-biased cellular response in BALB/c mice. The data in the current study demonstrate the potential of these lipids as promising candidates for LNP-based mRNA vaccines in general and for a COVID19 vaccine in particular.
  • |*COVID-19[MESH]
  • |*Nanoparticles[MESH]
  • |*Vaccines[MESH]
  • |Animals[MESH]
  • |Antibodies, Neutralizing[MESH]
  • |Antibodies, Viral[MESH]
  • |COVID-19 Vaccines[MESH]
  • |Humans[MESH]
  • |Lipids[MESH]
  • |Mice[MESH]
  • |Mice, Inbred BALB C[MESH]
  • |RNA, Messenger/genetics[MESH]
  • |SARS-CoV-2[MESH]


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