Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1042/CS20201042 http://scihub22266oqcxt.onion/10.1042/CS20201042 33480424!ä!33480424 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Clin+Sci+(Lond) 2021 ; 135 (2): 305-325 Nephropedia Template TP {{tp|p=33480424|t=2021. Host cell glutamine metabolism as a potential antiviral target |pdf=|usr=}}{{33480424}} gab.com Text Host cell glutamine metabolism as a potential antiviral target JO: Clin Sci (Lond) http://www.kidney.de/pget.php?&tw=1&pmid=33480424 #FOAvip A virus minimally contains a nucleic acid genome packaged by a protein coat. The genome and capsid together are known as the nucleocapsid, which has an envelope containing a lipid bilayer (mainly phospholipids) originating from host cell membranes. The viral envelope has transmembrane proteins that are usually glycoproteins. The proteins in the envelope bind to host cell receptors, promoting membrane fusion and viral entry into the cell. Virus-infected host cells exhibit marked increases in glutamine utilization and metabolism. Glutamine metabolism generates ATP and precursors for the synthesis of macromolecules to assemble progeny viruses. Some compounds derived from glutamine are used in the synthesis of purines and pyrimidines. These latter compounds are precursors for the synthesis of nucleotides. Inhibitors of glutamine transport and metabolism are potential candidate antiviral drugs. Glutamine is also an essential nutrient for the functions of leukocytes (lymphocyte, macrophage, and neutrophil), including those in virus-infected patients. The increased glutamine requirement for immune cell functions occurs concomitantly with the high glutamine utilization by host cells in virus-infected patients. The development of antiviral drugs that target glutamine metabolism must then be specifically directed at virus-infected host cells to avoid negative effects on immune functions. Therefore, the aim of this review was to describe the landscape of cellular glutamine metabolism to search for potential candidates to inhibit glutamine transport or glutamine metabolism. Twit Text FOAVip Host cell glutamine metabolism as a potential antiviral target ????Clin Sci (Lond) http://www.kidney.de/pget.php?&tw=1&pmid=33480424 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33480424 #FOAvip English Wikipedia <ref>{{Cite pmid|33480424}}</ref> Host cell glutamine metabolism as a potential antiviral target #MMPMID33480424 Hirabara SM; Gorjao R; Levada-Pires AC; Masi LN; Hatanaka E; Cury-Boaventura MF; da Silva EB; Santos-Oliveira LCD; Sousa Diniz VL; Serdan TAD; de Oliveira VAB; de Souza DR; Gritte RB; Souza-Siqueira T; Zambonatto RF; Pithon-Curi TC; Bazotte RB; Newsholme P; Curi R Clin Sci (Lond) 2021[Jan]; 135 (2): 305-325 PMID33480424show ga A virus minimally contains a nucleic acid genome packaged by a protein coat. The genome and capsid together are known as the nucleocapsid, which has an envelope containing a lipid bilayer (mainly phospholipids) originating from host cell membranes. The viral envelope has transmembrane proteins that are usually glycoproteins. The proteins in the envelope bind to host cell receptors, promoting membrane fusion and viral entry into the cell. Virus-infected host cells exhibit marked increases in glutamine utilization and metabolism. Glutamine metabolism generates ATP and precursors for the synthesis of macromolecules to assemble progeny viruses. Some compounds derived from glutamine are used in the synthesis of purines and pyrimidines. These latter compounds are precursors for the synthesis of nucleotides. Inhibitors of glutamine transport and metabolism are potential candidate antiviral drugs. Glutamine is also an essential nutrient for the functions of leukocytes (lymphocyte, macrophage, and neutrophil), including those in virus-infected patients. The increased glutamine requirement for immune cell functions occurs concomitantly with the high glutamine utilization by host cells in virus-infected patients. The development of antiviral drugs that target glutamine metabolism must then be specifically directed at virus-infected host cells to avoid negative effects on immune functions. Therefore, the aim of this review was to describe the landscape of cellular glutamine metabolism to search for potential candidates to inhibit glutamine transport or glutamine metabolism. |Antiviral Agents/*pharmacology[MESH] |Cell Line, Tumor[MESH] |Glutamine/*metabolism[MESH] |Host-Pathogen Interactions[MESH] |Humans[MESH] |Metabolic Networks and Pathways/*drug effects[MESH] |Neoplasms/metabolism/virology[MESH] |Virulence/drug effects[MESH] |Virus Replication/*drug effects[MESH]Host cell glutamine metabolism as a potential antiviral target (epmc).pdf DeepDyve Pubget Overpricing