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10.1021/acsmedchemlett.0c00485 http://scihub22266oqcxt.onion/10.1021/acsmedchemlett.0c00485 33479570!7737538!33479570     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       ACS+Med+Chem+Lett 2021 ; 12 (1): 88-92 Nephropedia Template TP {{tp|p=33479570|t=2021. Influence of 4 -Substitution on the Activity of Gemcitabine and Its ProTide Against VZV and SARS-CoV-2 |pdf=|usr=}}{{33479570}} gab.com Text Influence of 4 -Substitution on the Activity of Gemcitabine and Its ProTide Against VZV and SARS-CoV-2 JO: ACS Med Chem Lett http://www.kidney.de/pget.php?&tw=1&pmid=33479570 #FOAvip In addition to its therapeutic value as a chemotherapy drug, gemcitabine is of ongoing interest to the scientific community for its broad-spectrum antiviral activity. Herein the synthesis of 4'-methoxy- and 4'-fluoro-substituted gemcitabine analogues along with their phosphoramidate prodrugs is described. Among these derivatives, 4'-fluorogemcitabine proved to be active against varicella zoster virus (VZV, TK+ strain) with an EC(50) of 0.042 muM and produced significant cytotoxicity (CC(50) = 0.11 muM). Upon derivatization of this trifluoro nucleoside as its prodrug, decreased anti-VZV activity was observed, but with a concomitantly improved selectivity index (SI = 36). When this prodrug was tested against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), its antiviral activity (EC(50) = 0.73 muM) was comparable to or slightly lower than its cytotoxic concentration in measurements of cell growth and cell morphology, respectively. Twit Text FOAVip Influence of 4 -Substitution on the Activity of Gemcitabine and Its ProTide Against VZV and SARS-CoV-2 ????ACS Med Chem Lett http://www.kidney.de/pget.php?&tw=1&pmid=33479570 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33479570 #FOAvip English Wikipedia <ref>{{Cite pmid|33479570}}</ref> Influence of 4 -Substitution on the Activity of Gemcitabine and Its ProTide Against VZV and SARS-CoV-2 #MMPMID33479570 Zheng Z; Groaz E; Snoeck R; De Jonghe S; Herdewijn P; Andrei G ACS Med Chem Lett 2021[Jan]; 12 (1): 88-92 PMID33479570show ga In addition to its therapeutic value as a chemotherapy drug, gemcitabine is of ongoing interest to the scientific community for its broad-spectrum antiviral activity. Herein the synthesis of 4'-methoxy- and 4'-fluoro-substituted gemcitabine analogues along with their phosphoramidate prodrugs is described. Among these derivatives, 4'-fluorogemcitabine proved to be active against varicella zoster virus (VZV, TK+ strain) with an EC(50) of 0.042 muM and produced significant cytotoxicity (CC(50) = 0.11 muM). Upon derivatization of this trifluoro nucleoside as its prodrug, decreased anti-VZV activity was observed, but with a concomitantly improved selectivity index (SI = 36). When this prodrug was tested against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), its antiviral activity (EC(50) = 0.73 muM) was comparable to or slightly lower than its cytotoxic concentration in measurements of cell growth and cell morphology, respectively. äInfluence of 4 -Substitution on the Activity of Gemcitabine and Its Pr(epmc).pdf DeepDyve Pubget Overpricing