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10.1038/s41467-020-20768-y

http://scihub22266oqcxt.onion/10.1038/s41467-020-20768-y
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33479198!7820290!33479198
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suck abstract from ncbi


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pmid33479198      Nat+Commun 2021 ; 12 (1): 502
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  • The SARS-CoV-2 nucleocapsid phosphoprotein forms mutually exclusive condensates with RNA and the membrane-associated M protein #MMPMID33479198
  • Lu S; Ye Q; Singh D; Cao Y; Diedrich JK; Yates JR 3rd; Villa E; Cleveland DW; Corbett KD
  • Nat Commun 2021[Jan]; 12 (1): 502 PMID33479198show ga
  • The multifunctional nucleocapsid (N) protein in SARS-CoV-2 binds the ~30 kb viral RNA genome to aid its packaging into the 80-90 nm membrane-enveloped virion. The N protein is composed of N-terminal RNA-binding and C-terminal dimerization domains that are flanked by three intrinsically disordered regions. Here we demonstrate that the N protein's central disordered domain drives phase separation with RNA, and that phosphorylation of an adjacent serine/arginine rich region modulates the physical properties of the resulting condensates. In cells, N forms condensates that recruit the stress granule protein G3BP1, highlighting a potential role for N in G3BP1 sequestration and stress granule inhibition. The SARS-CoV-2 membrane (M) protein independently induces N protein phase separation, and three-component mixtures of N + M + RNA form condensates with mutually exclusive compartments containing N + M or N + RNA, including annular structures in which the M protein coats the outside of an N + RNA condensate. These findings support a model in which phase separation of the SARS-CoV-2 N protein contributes both to suppression of the G3BP1-dependent host immune response and to packaging genomic RNA during virion assembly.
  • |COVID-19/genetics/metabolism/*virology[MESH]
  • |Cell Membrane/virology[MESH]
  • |Coronavirus Nucleocapsid Proteins/chemistry/genetics/*metabolism[MESH]
  • |DNA Helicases/genetics/metabolism[MESH]
  • |Humans[MESH]
  • |Phosphoproteins/chemistry/genetics/metabolism[MESH]
  • |Poly-ADP-Ribose Binding Proteins/genetics/metabolism[MESH]
  • |Protein Binding[MESH]
  • |Protein Domains[MESH]
  • |RNA Helicases/genetics/metabolism[MESH]
  • |RNA Recognition Motif Proteins/genetics/metabolism[MESH]
  • |RNA, Viral/genetics/*metabolism[MESH]
  • |SARS-CoV-2/chemistry/genetics/*metabolism[MESH]


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