Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1126/sciimmunol.abe4782 http://scihub22266oqcxt.onion/10.1126/sciimmunol.abe4782 33478949!8101257!33478949     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Immunol 2021 ; 6 (55): ä Nephropedia Template TP {{tp|p=33478949|t=2021. Severely ill COVID-19 patients display impaired exhaustion features in SARS-CoV-2-reactive CD8(+) T cells |pdf=|usr=}}{{33478949}} gab.com Text Severely ill COVID-19 patients display impaired exhaustion features in SARS-CoV-2-reactive CD8(+) T cells JO: Sci Immunol http://www.kidney.de/pget.php?&tw=1&pmid=33478949 #FOAvip The molecular properties of CD8(+) T cells that respond to SARS-CoV-2 infection are not fully known. Here, we report on the single-cell transcriptomes of >80,000 virus-reactive CD8(+) T cells, obtained using a modified Antigen-Reactive T cell Enrichment (ARTE) assay, from 39 COVID-19 patients and 10 healthy subjects. COVID-19 patients segregated into two groups based on whether the dominant CD8(+) T cell response to SARS-CoV-2 was 'exhausted' or not. SARS-CoV-2-reactive cells in the exhausted subset were increased in frequency and displayed lesser cytotoxicity and inflammatory features in COVID-19 patients with mild compared to severe illness. In contrast, SARS-CoV-2-reactive cells in the dominant non-exhausted subset from patients with severe disease showed enrichment of transcripts linked to co-stimulation, pro-survival NF-kappaB signaling, and anti-apoptotic pathways, suggesting the generation of robust CD8(+) T cell memory responses in patients with severe COVID-19 illness. CD8(+) T cells reactive to influenza and respiratory syncytial virus from healthy subjects displayed polyfunctional features and enhanced glycolysis. Cells with such features were largely absent in SARS-CoV-2-reactive cells from both COVID-19 patients and healthy controls non-exposed to SARS-CoV-2. Overall, our single-cell analysis revealed substantial diversity in the nature of CD8(+) T cells responding to SARS-CoV-2. Twit Text FOAVip Severely ill COVID-19 patients display impaired exhaustion features in SARS-CoV-2-reactive CD8(+) T cells ????Sci Immunol http://www.kidney.de/pget.php?&tw=1&pmid=33478949 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33478949 #FOAvip English Wikipedia <ref>{{Cite pmid|33478949}}</ref> Severely ill COVID-19 patients display impaired exhaustion features in SARS-CoV-2-reactive CD8(+) T cells #MMPMID33478949 Kusnadi A; Ramirez-Suastegui C; Fajardo V; Chee SJ; Meckiff BJ; Simon H; Pelosi E; Seumois G; Ay F; Vijayanand P; Ottensmeier CH Sci Immunol 2021[Jan]; 6 (55): ä PMID33478949show ga The molecular properties of CD8(+) T cells that respond to SARS-CoV-2 infection are not fully known. Here, we report on the single-cell transcriptomes of >80,000 virus-reactive CD8(+) T cells, obtained using a modified Antigen-Reactive T cell Enrichment (ARTE) assay, from 39 COVID-19 patients and 10 healthy subjects. COVID-19 patients segregated into two groups based on whether the dominant CD8(+) T cell response to SARS-CoV-2 was 'exhausted' or not. SARS-CoV-2-reactive cells in the exhausted subset were increased in frequency and displayed lesser cytotoxicity and inflammatory features in COVID-19 patients with mild compared to severe illness. In contrast, SARS-CoV-2-reactive cells in the dominant non-exhausted subset from patients with severe disease showed enrichment of transcripts linked to co-stimulation, pro-survival NF-kappaB signaling, and anti-apoptotic pathways, suggesting the generation of robust CD8(+) T cell memory responses in patients with severe COVID-19 illness. CD8(+) T cells reactive to influenza and respiratory syncytial virus from healthy subjects displayed polyfunctional features and enhanced glycolysis. Cells with such features were largely absent in SARS-CoV-2-reactive cells from both COVID-19 patients and healthy controls non-exposed to SARS-CoV-2. Overall, our single-cell analysis revealed substantial diversity in the nature of CD8(+) T cells responding to SARS-CoV-2. |Adult[MESH] |Aged[MESH] |Aged, 80 and over[MESH] |CD8-Positive T-Lymphocytes/*immunology[MESH] |COVID-19/*immunology[MESH] |Female[MESH] |Glycolysis/immunology[MESH] |Humans[MESH] |Immunologic Memory/immunology[MESH] |Male[MESH] |Middle Aged[MESH] |NF-kappa B/immunology[MESH] |SARS-CoV-2/*immunology[MESH] |Signal Transduction/immunology[MESH] |Single-Cell Analysis/methods[MESH]Severely ill COVID-19 patients display impaired exhaustion features in(epmc).pdf DeepDyve Pubget Overpricing