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10.2807/1560-7917.ES.2021.26.3.2100008

http://scihub22266oqcxt.onion/10.2807/1560-7917.ES.2021.26.3.2100008
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33478625!7848679!33478625
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suck abstract from ncbi


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pmid33478625      Euro+Surveill 2021 ; 26 (3): ä
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  • Two-step strategy for the identification of SARS-CoV-2 variant of concern 202012/01 and other variants with spike deletion H69-V70, France, August to December 2020 #MMPMID33478625
  • Bal A; Destras G; Gaymard A; Stefic K; Marlet J; Eymieux S; Regue H; Semanas Q; d'Aubarede C; Billaud G; Laurent F; Gonzalez C; Mekki Y; Valette M; Bouscambert M; Gaudy-Graffin C; Lina B; Morfin F; Josset L
  • Euro Surveill 2021[Jan]; 26 (3): ä PMID33478625show ga
  • We report the strategy leading to the first detection of variant of concern 202012/01 (VOC) in France (21 December 2020). First, the spike (S) deletion H69-V70 (DeltaH69/DeltaV70), identified in certain SARS-CoV-2 variants including VOC, is screened for. This deletion is associated with a S-gene target failure (SGTF) in the three-target RT-PCR assay (TaqPath kit). Subsequently, SGTF samples are whole genome sequenced. This approach revealed mutations co-occurring with DeltaH69/DeltaV70 including S:N501Y in the VOC.
  • |*Base Sequence[MESH]
  • |*Genome, Viral[MESH]
  • |COVID-19/*epidemiology[MESH]
  • |France/epidemiology[MESH]
  • |Humans[MESH]
  • |SARS-CoV-2/*genetics[MESH]
  • |Sequence Deletion/*genetics[MESH]


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